Kossuga Miriam H, MacMillan John B, Rogers Evan W, Molinski Tadeusz F, Nascimento Gislene G F, Rocha Rosana M, Berlinck Roberto G S
Instituto de Química de São Carlos, Universidade de São Paulo, CP 780, CEP 13560-970, São Carlos, SP, Brazil.
J Nat Prod. 2004 Nov;67(11):1879-81. doi: 10.1021/np049782q.
A new antifungal agent, (2S,3R)-2-aminododecan-3-ol (1), has been isolated from the ascidian Clavelina oblonga collected in Brazil. The structure of 1 was established by analysis of spectroscopic data, including absolute stereochemistry determined by circular dichroism analysis of the dibenzoyl derivative 2. Compound 1 displayed antifungal activity against Candida albicans ATCC 10231 with a MIC of 0.7 mug/mL and against Candida glabrata with a MIC of 30 microg/mL.
一种新的抗真菌剂，(2S,3R)-2-氨基十二烷-3-醇(1)，已从在巴西采集的海鞘长形柄海鞘中分离出来。通过光谱数据分析确定了1的结构，包括通过二苯甲酰衍生物2的圆二色性分析确定的绝对立体化学结构。化合物1对白色念珠菌ATCC 10231显示出抗真菌活性，最低抑菌浓度(MIC)为0.7μg/mL，对光滑念珠菌的MIC为30μg/mL。
