Anca Ioana Alina, Furtunescu Florentina Ligia, Pleşca Doina, Streinu-Cercel Adrian, Rugină Sorin, Holl Katsiaryna
MD, PhD, Carol Davila University of Medicine and Pharmacy; Institute For Mother and Child Care, Bucharest 020395, Romania.
MD, PhD, Department of Complementary Sciences, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest 050463, Romania.
Germs. 2014 Jun 2;4(2):30-40. doi: 10.11599/germs.2014.1053. eCollection 2014 Jun.
Rotavirus (RV) is a leading cause of acute gastroenteritis (AGE), affecting 95% of children below five years of age.
In this prospective, multi-center study, children below five years of age who were hospitalized or those who visited the emergency room (ER) due to AGE or who developed AGE at least 48 hours after hospitalization (nosocomial infection) and had a RV-positive stool sample were included (n=1,222). RV-positive samples were genotyped by reverse-transcriptase polymerase chain reaction.
RV test results were available for 1,212 children (hospitalizations [n=677], ER visits [n=398] and nosocomial AGE cases [n=137]). Proportions of rotavirus gastroenteritis (RVGE) hospitalizations and ER visits were 51.70% (350/677; 95%CI: 47.86-55.52) and 36.18% (144/398; 95%CI: 31.45-41.12), respectively. Overall, 45.95% (494/1075) of all community-acquired AGE cases were due to RV. High numbers of RVGE cases were recorded between January and March. Most common genotypes were G9P[8] (34.27%) followed by G4P[8] (25.83%) and G1P[8] (23.02%). Of all community-acquired RVGE cases, the highest number of cases was observed in children aged 12-23 months. Median duration of hospitalization among RV-positive subjects was six days (range: 2-31 days). Incidence of nosocomial RVGE was 0.52 (95%CI: 0.45-0.60) cases per 1,000 child-days hospitalization. Median duration for additional hospitalization due to nosocomial RVGE was five days (range: 1-10). The highest burden of nosocomial RVGE was observed in children aged 12-23 months (42.34%, 58/137). Our findings confirm a high burden of acute RVGE disease in Romania and provide useful data to support the implementation of RV vaccination in Romania.
NCT01253967.
轮状病毒（RV）是急性胃肠炎（AGE）的主要病因，影响95%的五岁以下儿童。
在这项前瞻性多中心研究中，纳入了五岁以下因AGE住院的儿童、因AGE就诊于急诊室（ER）的儿童或住院至少48小时后发生AGE（医院感染）且粪便样本RV呈阳性的儿童（n = 1222）。通过逆转录聚合酶链反应对RV阳性样本进行基因分型。
1212名儿童有RV检测结果（住院患者[n = 677]、急诊就诊患者[n = 398]和医院感染AGE病例[n = 137]）。轮状病毒胃肠炎（RVGE）住院和急诊就诊的比例分别为51.70%（350/677；95%CI：47.86 - 55.52）和36.18%（144/398；95%CI：31.45 - 41.12）。总体而言，所有社区获得性AGE病例中有45.95%（494/1075）是由RV引起的。1月至3月记录到大量RVGE病例。最常见的基因型是G9P[8]（34.27%），其次是G4P[8]（25.83%）和G1P[8]（23.02%）。在所有社区获得性RVGE病例中，12至23个月大的儿童病例数最多。RV阳性受试者的住院中位时长为6天（范围：2 - 31天）。医院感染性RVGE的发病率为每1000儿童住院日0.52例（95%CI：0.45 - 0.60）。因医院感染性RVGE导致的额外住院中位时长为5天（范围：1 - 10天）。12至23个月大的儿童医院感染性RVGE负担最高（42.34%，58/137）。我们的研究结果证实了罗马尼亚急性RVGE疾病的高负担，并提供了有用的数据来支持罗马尼亚实施RV疫苗接种。
NCT01253967。
