Howard Susan Julie
Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK,
Mycopathologia. 2014 Dec;178(5-6):435-9. doi: 10.1007/s11046-014-9774-0. Epub 2014 Jun 27.
Reports of cryptic species causing aspergillosis in humans are increasing in the literature. Cryptic species are defined as those which are morphologically indistinguishable, although their identifications can be confirmed using molecular or other techniques which continue to become more widely available in the clinical setting. Antifungal resistance has often been noted in these cases, and indeed there does appear to be a higher prevalence of reduced susceptibility in cryptic species. Many of these observations are published as individual case reports or as a small component of larger data sets, making it challenging to review and compare the data fully. This review article seeks to describe the susceptibility trends and key learning outcomes of specific cases of infections caused by cryptic species, including Aspergillus alliaceus, Aspergillus calidoustus, Aspergillus felis, Aspergillus lentulus, Aspergillus tubingensis, Aspergillus viridinutans and Neosartorya pseudofischeri. These reports highlight the clinical need for full accurate identification and susceptibility testing to guide patient care.
文献中关于引起人类曲霉病的隐性菌种的报道越来越多。隐性菌种是指那些在形态上无法区分的菌种，不过可以使用分子技术或其他技术来确认其身份，而这些技术在临床环境中越来越普及。在这些病例中经常发现抗真菌耐药性，实际上隐性菌种中药敏性降低的发生率似乎更高。许多这些观察结果都是作为个案报告或作为更大数据集的一小部分发表的，这使得全面审查和比较数据具有挑战性。这篇综述文章旨在描述由隐性菌种引起的特定感染病例的药敏趋势和关键经验教训，包括蒜曲霉、热栖曲霉、猫曲霉、勒图曲霉、土曲霉、绿褐曲霉和假费氏新萨托菌。这些报告强调了全面准确鉴定和药敏试验以指导患者护理的临床需求。
