Chen Ling, Shi Ying, Liu Shuang, Cao Ya, Wang Xiang, Tao Yongguang
Cancer Research Institute, Central South University, Changsha 410078, China.
Center for Medicine Research, Xiangya Hospital, Central South University, Changsha 410008, China.
Int J Mol Sci. 2014 Jun 26;15(7):11435-45. doi: 10.3390/ijms150711435.
Cancer metabolism reprogramming or alterations in epigenetics are linked to an incidence of cancer. It is apparent that epigenetic changes have been found in tumors, therefore, the complete epigenome and entire pathways relevant to cell metabolism are subject to epigenetic dysregulation. Here, we review the pyruvate kinase M2 (PKM2) isoform, a glycolytic enzyme involved in ATP generation and pyruvate production, which plays an essential role in tumor metabolism and growth, and also functions as a protein kinase that phosphorylates histones during genes transcription and chromatin remodeling. We also discuss the potential role of PKM2 in the dynamic integration between metabolic reprogramming and alterations in epigenetics during carcinogenesis and cancer progression.
癌症代谢重编程或表观遗传学改变与癌症发病率相关。显然，肿瘤中已发现表观遗传变化，因此，与细胞代谢相关的完整表观基因组和整个通路都受到表观遗传失调的影响。在此，我们综述丙酮酸激酶M2（PKM2）亚型，这是一种参与ATP生成和丙酮酸产生的糖酵解酶，它在肿瘤代谢和生长中起重要作用，并且在基因转录和染色质重塑过程中作为一种蛋白激酶使组蛋白磷酸化。我们还讨论了PKM2在致癌作用和癌症进展过程中代谢重编程与表观遗传学改变之间动态整合中的潜在作用。
