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Sequence and organization of the mouse poly (ADP-ribose) polymerase gene.

作者信息

Huppi K, Bhatia K, Siwarski D, Klinman D, Cherney B, Smulson M

机构信息

Laboratory of Genetics, NCI, Bethesda, MD 20892.

出版信息

Nucleic Acids Res. 1989 May 11;17(9):3387-401. doi: 10.1093/nar/17.9.3387.

DOI:10.1093/nar/17.9.3387
PMID:2498841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC317782/
Abstract

Using a human cDNA probe, we have isolated murine genomic and cDNA clones corresponding to the nuclear enzyme poly (ADP-ribose) polymerase (ADPRP). Northern analysis with the mouse cDNA clones reveals transcripts of 3.7-3.8 kb corresponding in size to the human ADPRP transcript. DNA sequence comparisons between mouse and human clones reveals extensive amino acid sequence conservation within regions harboring DNA binding, NAD+ binding or automodification domains. A survey among mouse inbred strains for restriction fragment length polymorphism (RFLP) reveals at least three distinct ADPRP alleles. The segregation of alleles among mouse genetic recombinants positions ADPRP on mouse chromosome 1 between the complement receptor-related gene At-3 and the Fc receptor locus FcR. Furthermore, ADPRP is closely associated with the autoimmune locus gld (generalized lymphadenopathy).

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a76/317782/30e6457632f3/nar00126-0076-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a76/317782/e88ca2b90cc4/nar00126-0068-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a76/317782/d7c8f19c6615/nar00126-0073-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a76/317782/11b25b03f53f/nar00126-0074-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a76/317782/e387139fab69/nar00126-0075-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a76/317782/30e6457632f3/nar00126-0076-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a76/317782/e88ca2b90cc4/nar00126-0068-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a76/317782/d7c8f19c6615/nar00126-0073-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a76/317782/11b25b03f53f/nar00126-0074-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a76/317782/e387139fab69/nar00126-0075-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a76/317782/30e6457632f3/nar00126-0076-a.jpg

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引用本文的文献

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Detection of DNA breaks in apoptotic cells utilizing the DNA binding domain of poly(ADP-ribose) polymerase with fluorescence microscopy.利用聚（ADP-核糖）聚合酶的DNA结合结构域通过荧光显微镜检测凋亡细胞中的DNA断裂。
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2
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本文引用的文献

1
Murine DNA repair gene located on chromosome 4.
Nature. 1981 Jan 15;289(5794):191-4. doi: 10.1038/289191a0.
2
A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice.一种新的突变体gld，它在C3H/HeJ小鼠中引发淋巴细胞增殖和自身免疫。
J Exp Med. 1984 Jan 1;159(1):1-20. doi: 10.1084/jem.159.1.1.
3
DNA rearrangement and altered RNA expression of the c-myb oncogene in mouse plasmacytoid lymphosarcomas.小鼠浆细胞样淋巴瘤中c-myb癌基因的DNA重排及RNA表达改变
聚（ADP - 核糖）聚合酶活性的抑制可阻断逆转录病毒对哺乳动物细胞的有效感染。
J Virol. 1996 Jun;70(6):3992-4000. doi: 10.1128/JVI.70.6.3992-4000.1996.
4
Cloning of cDNA encoding Drosophila poly(ADP-ribose) polymerase: leucine zipper in the auto-modification domain.果蝇聚（ADP - 核糖）聚合酶编码cDNA的克隆：自身修饰结构域中的亮氨酸拉链
Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3481-5. doi: 10.1073/pnas.90.8.3481.
5
Molecular and biochemical features of poly (ADP-ribose) metabolism.聚（ADP - 核糖）代谢的分子和生化特征
Mol Cell Biochem. 1993 May 26;122(2):171-93. doi: 10.1007/BF01076101.
6
Genetic mapping of tumor susceptibility genes involved in mouse plasmacytomagenesis.参与小鼠浆细胞瘤发生的肿瘤易感性基因的遗传定位。
Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9499-503. doi: 10.1073/pnas.90.20.9499.
7
Poly(ADP-ribose) polymerase: structural conservation among different classes of animals and its implications.
Mol Cell Biochem. 1994 Sep;138(1-2):25-32. doi: 10.1007/BF00928439.
8
Structure and function of poly(ADP-ribose) polymerase.
Mol Cell Biochem. 1994 Sep;138(1-2):15-24. doi: 10.1007/BF00928438.
9
trans-dominant inhibition of poly(ADP-ribosyl)ation sensitizes cells against gamma-irradiation and N-methyl-N'-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyomavirus replicon.聚（ADP - 核糖基）化的反式显性抑制使细胞对γ射线和N - 甲基 - N'- 硝基 - N - 亚硝基胍敏感，但不限制多瘤病毒复制子的DNA复制。
Mol Cell Biol. 1995 Jun;15(6):3154-63. doi: 10.1128/MCB.15.6.3154.
10
The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA.聚（ADP-核糖）聚合酶的第二个锌指结构域决定了对DNA单链断裂的特异性。
Proc Natl Acad Sci U S A. 1990 Apr;87(8):2990-4. doi: 10.1073/pnas.87.8.2990.
Science. 1983 May 20;220(4599):795-8. doi: 10.1126/science.6687762.
4
Poly(ADP-ribose) synthesis in vitro programmed by damaged DNA. A comparison of DNA molecules containing different types of strand breaks.受损DNA体外编程的聚（ADP - 核糖）合成。含有不同类型链断裂的DNA分子的比较。
J Biol Chem. 1980 Nov 10;255(21):10502-8.
5
Suppression and reappearance of N-tropic L virus production in somatic cell hybrids after introduction and loss of chromosomes carrying Fv-1b.携带Fv-1b的染色体导入和丢失后，体细胞杂种中N-嗜性L病毒产生的抑制与再现。
Eur J Cancer (1965). 1980 Mar;16(3):357-68. doi: 10.1016/0014-2964(80)90353-9.
6
Lymphocyte dysfunction after DNA damage by toxic oxygen species. A model of immunodeficiency.有毒氧物种造成DNA损伤后的淋巴细胞功能障碍。一种免疫缺陷模型。
J Exp Med. 1986 Mar 1;163(3):746-51. doi: 10.1084/jem.163.3.746.
7
Statistical considerations for linkage analysis using recombinant inbred strains and backcrosses.使用重组近交系和回交进行连锁分析的统计学考量。
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Genes on chromosomes 1 and 4 in the mouse are associated with repair of radiation-induced chromatin damage.小鼠1号和4号染色体上的基因与辐射诱导的染色质损伤修复有关。
Genomics. 1988 Apr;2(3):257-62. doi: 10.1016/0888-7543(88)90010-9.