猫后睾吸虫基因组为胆管内的生命活动提供了见解。
The Opisthorchis viverrini genome provides insights into life in the bile duct.
作者信息
Young Neil D, Nagarajan Niranjan, Lin Suling Joyce, Korhonen Pasi K, Jex Aaron R, Hall Ross S, Safavi-Hemami Helena, Kaewkong Worasak, Bertrand Denis, Gao Song, Seet Qihui, Wongkham Sopit, Teh Bin Tean, Wongkham Chaisiri, Intapan Pewpan Maleewong, Maleewong Wanchai, Yang Xinhua, Hu Min, Wang Zuo, Hofmann Andreas, Sternberg Paul W, Tan Patrick, Wang Jun, Gasser Robin B
机构信息
1] Faculty of Veterinary Science, The University of Melbourne, Melbourne, Victoria 3010, Australia [2].
1] Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Republic of Singapore [2].
出版信息
Nat Commun. 2014 Jul 9;5:4378. doi: 10.1038/ncomms5378.
Opisthorchiasis is a neglected, tropical disease caused by the carcinogenic Asian liver fluke, Opisthorchis viverrini. This hepatobiliary disease is linked to malignant cancer (cholangiocarcinoma, CCA) and affects millions of people in Asia. No vaccine is available, and only one drug (praziquantel) is used against the parasite. Little is known about O. viverrini biology and the diseases that it causes. Here we characterize the draft genome (634.5 Mb) and transcriptomes of O. viverrini, elucidate how this fluke survives in the hostile environment within the bile duct and show that metabolic pathways in the parasite are highly adapted to a lipid-rich diet from bile and/or cholangiocytes. We also provide additional evidence that O. viverrini and other flukes secrete proteins that directly modulate host cell proliferation. Our molecular resources now underpin profound explorations of opisthorchiasis/CCA and the design of new interventions.
华支睾吸虫病是一种被忽视的热带疾病，由致癌的亚洲肝吸虫华支睾吸虫引起。这种肝胆疾病与恶性癌症（胆管癌，CCA）有关，影响着亚洲数百万人。目前尚无疫苗可用，针对该寄生虫仅使用一种药物（吡喹酮）。人们对华支睾吸虫的生物学特性及其所引发的疾病知之甚少。在此，我们对华支睾吸虫的基因组草图（634.5兆字节）和转录组进行了表征，阐明了这种吸虫如何在胆管内的恶劣环境中生存，并表明该寄生虫的代谢途径高度适应来自胆汁和/或胆管细胞的富含脂质的饮食。我们还提供了更多证据，证明华支睾吸虫和其他吸虫会分泌直接调节宿主细胞增殖的蛋白质。我们的分子资源现在为深入探索华支睾吸虫病/胆管癌以及设计新的干预措施奠定了基础。
Zotero 插件