Department of Ophthalmology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Department of Ophthalmology, Hospital Universitario Vall d'Hebrón, 08035 Barcelona, Spain ; Red Temática de Investigación Cooperativa en Oftalmología (RETICS-Oftared RD12/0034), Instituto de Salud Carlos III, Madrid, Spain.
Biomed Res Int. 2014;2014:458631. doi: 10.1155/2014/458631. Epub 2014 Jul 7.
To evaluate macular retinal ganglion cell-inner plexiform layer (GCIPL) thickness changes after Brilliant Blue G-assisted internal limiting membrane peeling for idiopathic macular hole repair using a high-resolution spectral-domain optical coherence tomography (SD-OCT).
32 eyes from 32 patients with idiopathic macular holes who underwent vitrectomy with internal limiting membrane peeling between January 2011 and July 2012 were retrospectively analyzed. GCIPL thickness was measured before surgery, and at one month and at six months after surgery. Values obtained from automated and semimanual SD-OCT segmentation analysis were compared (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin, CA).
No significant differences were found between average GCIPL thickness values between preoperative and postoperative analysis. However, statistical significant differences were found in GCIPL thickness at the temporal macular quadrants at six months after surgery. Quality measurement analysis performed by automated segmentation revealed a significant number of segmentation errors. Semimanual segmentation slightly improved the quality of the results.
SD-OCT analysis of GCIPL thickness found a significant reduction at the temporal macular quadrants at 6 months after Brilliant Blue G-assisted internal limiting membrane peeling for idiopathic macular hole.
使用高分辨率谱域光学相干断层扫描（SD-OCT）评估 Brilliant Blue G 辅助内界膜剥除治疗特发性黄斑裂孔修复后黄斑视网膜神经节细胞-内丛状层（GCIPL）厚度的变化。
回顾性分析 2011 年 1 月至 2012 年 7 月间接受玻璃体切割联合内界膜剥除术治疗的 32 例特发性黄斑裂孔患者的 32 只眼。在术前、术后 1 个月和 6 个月测量 GCIPL 厚度。比较自动和半手动 SD-OCT 分割分析获得的数值（Cirrus HD-OCT，Carl Zeiss Meditec，都柏林，CA）。
平均 GCIPL 厚度值在术前和术后分析之间无显著差异。然而，术后 6 个月时颞侧黄斑象限的 GCIPL 厚度存在统计学显著差异。自动分割的质量测量分析显示存在大量分割错误。半手动分割稍微改善了结果的质量。
Brilliant Blue G 辅助内界膜剥除治疗特发性黄斑裂孔后，SD-OCT 分析发现颞侧黄斑象限的 GCIPL 厚度在 6 个月时显著减少。
