He Huacheng, Cattran Alexander W, Nguyen Tu, Nieminen Anna-Liisa, Xu Peisheng
Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA.
Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, Medical University of South Carolina, Charleston, SC 29425, USA.
Biomaterials. 2014 Nov;35(35):9546-53. doi: 10.1016/j.biomaterials.2014.08.004. Epub 2014 Aug 22.
A pH, thermal, and redox potential triple-responsive expansile nanogel system (TRN), which swells at acidic pH, temperature higher than its transition temperature, and reducing environment, has been developed. TRN quickly expands from 108 nm to over 1200 nm (in diameter), achieving more than 1000-fold size enlargement (in volume), within 2 h in a reducing environment at body temperature. Sigma-2 receptor targeting-ligand functionalized TRN can effectively target head and neck tumor, and help Pc 4 targeting mitochondria inside cancer cells to achieve enhanced photodynamic therapy efficacy.
一种pH、热和氧化还原电位三响应膨胀纳米凝胶系统（TRN）已被开发出来，该系统在酸性pH值、高于其转变温度的温度以及还原环境下会膨胀。在体温下的还原环境中，TRN能在2小时内迅速从108纳米膨胀至超过1200纳米（直径），体积增大超过1000倍。靶向西格玛-2受体的配体功能化TRN能有效靶向头颈肿瘤，并帮助Pc 4靶向癌细胞内的线粒体，以提高光动力治疗效果。
