Department of Textile Technology, Indian Institute of Technology, New Delhi 110016, India.
Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.
Adv Drug Deliv Rev. 2015 Apr;84:107-22. doi: 10.1016/j.addr.2014.08.010. Epub 2014 Aug 29.
Cartilage tissue engineering has primarily focused on the generation of grafts to repair cartilage defects due to traumatic injury and disease. However engineered cartilage tissues have also a strong scientific value as advanced 3D culture models. Here we first describe key aspects of embryonic chondrogenesis and possible cell sources/culture systems for in vitro cartilage generation. We then review how a tissue engineering approach has been and could be further exploited to investigate different aspects of cartilage development and degeneration. The generated knowledge is expected to inform new cartilage regeneration strategies, beyond a classical tissue engineering paradigm.
软骨组织工程主要集中在生成移植物以修复创伤和疾病引起的软骨缺陷。然而，工程化软骨组织也具有很强的科学价值，可作为先进的 3D 培养模型。在这里，我们首先描述胚胎软骨发生的关键方面和体外软骨生成的可能细胞来源/培养系统。然后，我们回顾了组织工程方法的应用现状，并探讨了如何进一步利用该方法来研究软骨发育和退变的不同方面。预计所获得的知识将为软骨再生策略提供信息，超越传统的组织工程范例。
