Lee Y, Zacharias N M, Piwnica-Worms D, Bhattacharya P K
Hanyang University, Department of Applied Chemistry, Ansan, 426-791, Korea.
Chem Commun (Camb). 2014 Nov 7;50(86):13030-3. doi: 10.1039/c4cc06199c.
Here we present a novel hyperpolarization method, Chemical Reaction-Induced Multi-molecular Polarization (CRIMP), which could be applied to the study of several in vivo processes simultaneously including glycolysis, TCA cycle, fatty acid synthesis and pH mapping. Through the use of non-enzymatic decarboxylation, we generate four hyperpolarized imaging agents from hyperpolarized 1,2-(13)C pyruvic acid.
在此，我们提出了一种新型的超极化方法——化学反应诱导多分子极化（CRIMP），该方法可同时应用于多个体内过程的研究，包括糖酵解、三羧酸循环、脂肪酸合成以及pH映射。通过使用非酶脱羧反应，我们从超极化的1,2-(13)C丙酮酸生成了四种超极化成像剂。
