Abdolsamadi Hamidreza, Rafieian Nasrin, Goodarzi Mohammad Taghi, Feradmal Javad, Davoodi Poorandokht, Jazayeri Mina, Taghavi Zahrasadat, Hoseyni Seyed-Mostafa, Ahmadi-Motamayel Fatemeh
Dental Research Center, Department of Oral Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Research Center for Molecular Medicine, Department of Biochemistry and Nutrition, Hamadan University of Medical Sciences, Hamadan, Iran.
Chonnam Med J. 2014 Aug;50(2):58-62. doi: 10.4068/cmj.2014.50.2.58. Epub 2014 Aug 20.
Oral lichen planus (OLP) is a chronic inflammatory mucosal disease of unknown etiology. Many studies have implicated the protective role of antioxidants in such diseases. The aim of this study was to compare salivary total antioxidant capacity (TAC and malondialdehyde (MDA) and antioxidant vitamin (vitamin s A, C and E) levels in patients with erosive OLP and healthy individuals. Thirty six patients with OLP (14 males, 22 females) and 36 control subjects (15 males, 21 females), matched for age and sex were enrolled in this case control study. The salivary levels of MDA, TAC, and antioxidant vitamin levels were measured in both case and control groups. The salivary level of MDA was significantly higher (p<0.001) in patients than in controls. In patients with OLP, the TAC of saliva was significantly lower than that in healthy subjects (p<0.001). Compared with controls, the levels of salivary antioxidant vitamins were significantly decreased in patients with OLP (p<0.001). In addition, a positive correlation was found between the decrease in the salivary amount of vitamin C and that in vitamin E in patients and controls. In addition to the lower salivary levels of antioxidant vitamins and the lower TAC, the higher level of MDA in patients with OLP suggests that free radicals and the resulting oxidative damage may be important in the pathogenesis of OLP lesions.
口腔扁平苔藓（OLP）是一种病因不明的慢性炎症性黏膜疾病。许多研究表明抗氧化剂在这类疾病中具有保护作用。本研究的目的是比较糜烂型OLP患者与健康个体唾液中的总抗氧化能力（TAC）、丙二醛（MDA）以及抗氧化维生素（维生素A、C和E）水平。36例OLP患者（男14例，女22例）和36例对照者（男15例，女21例），年龄和性别相匹配，纳入本病例对照研究。测量了病例组和对照组唾液中MDA、TAC以及抗氧化维生素水平。患者唾液中MDA水平显著高于对照组（p<0.001）。OLP患者唾液中的TAC显著低于健康受试者（p<0.001）。与对照组相比，OLP患者唾液中抗氧化维生素水平显著降低（p<0.001）。此外，患者和对照组中唾液维生素C含量的降低与维生素E含量的降低之间存在正相关。除了唾液中抗氧化维生素水平较低和TAC较低外，OLP患者中较高的MDA水平表明自由基及其导致的氧化损伤可能在OLP病变的发病机制中起重要作用。
