Sletten Ellen M, Swager Timothy M
Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
J Am Chem Soc. 2014 Oct 1;136(39):13574-7. doi: 10.1021/ja507848f. Epub 2014 Sep 17.
"Fluoro" refers to both fluorescent and fluorinated compounds. Despite the shared prefix, there are very few fluorescent molecules that are soluble in perfluorinated solvents. This paucity is surprising, given that optical microscopy is a ubiquitous technique throughout the physical sciences and the orthogonality of fluorous materials is a commonly exploited strategy in synthetic chemistry, materials science, and chemical biology. We have addressed this shortage by synthesizing a panel of "fluorofluorophores," fluorescent molecules containing high weight percent fluorine with optical properties spanning the visible spectrum. We demonstrate the utility of these fluorofluorophores by preparing fluorescent perfluorocarbon nanoemulsions.
“氟代”既指荧光化合物，也指含氟化合物。尽管有共同的词头，但可溶于全氟溶剂的荧光分子却非常少。鉴于光学显微镜在整个物理科学领域都是一种普遍使用的技术，且氟代材料的正交性是合成化学、材料科学和化学生物学中常用的策略，这种稀缺性令人惊讶。我们通过合成一组“氟代荧光团”来解决这一短缺问题，这些荧光分子含有高重量百分比的氟，其光学性质涵盖了可见光谱。我们通过制备荧光全氟碳纳米乳液来证明这些氟代荧光团的实用性。
