Bélanger A, Locong A, Noel C, Cusan L, Dupont A, Prévost J, Caron S, Sévigny J
MRC Group in Molecular Endocrinology, Le Centre Hospitalier de l'Université Laval, Ste-Foy, Québec, Canada.
J Steroid Biochem. 1989 Jun;32(6):829-33. doi: 10.1016/0022-4731(89)90459-7.
Several experimental studies have suggested that diet can alter the production and metabolism of steroids in men. The purpose of this study was to determine the levels of unconjugated steroids and steroid glucuronides as well as sex hormone-binding globulin (SHBG) among normal adult men who were either omnivorous or vegetarians. The participants were white volunteers ranging from 25-35 years of age and the blood samples were taken between 0900 h and 1000 h and between 1600 h and 1700 h for two consecutive days. No significant statistical change was found in plasma dehydroepiandrosterone, dehydroepiandrosterone sulfate, testosterone, dihydrotestosterone and estradiol levels. Vegetarian group showed a higher levels of sex hormone-binding globulin (SHBG) while the free androgen index (FAI; calculated by the ratio testosterone/SHBG) was lower in this group. Although the concentrations of androsterone glucuronide were higher in vegetarian group, the vegetarians had a 25-50% lower level of androstane-3 alpha, 17 beta-diol glucuronide and androstane-3 beta,17 beta-diol glucuronide. Our data further indicate that both, androstane-3 alpha,17 beta-diol glucuronide and androstane-3 beta,17 beta-diol glucuronide concentrations are significantly correlated with SHBG levels and with the FAI values. The increases in androstane-3 alpha,17 beta-diol glucuronide and androstane-3 beta,17 beta-diol glucuronide levels in the omnivorous group are probably a consequence of the elevation of the FAI. Our data suggest that in a vegetarian group, less testosterone is available for androgenic action.
多项实验研究表明，饮食可改变男性体内类固醇的生成和代谢。本研究的目的是测定杂食或素食的正常成年男性中未结合类固醇、类固醇葡萄糖醛酸苷以及性激素结合球蛋白（SHBG）的水平。参与者为年龄在25至35岁之间的白人志愿者，连续两天在09:00至10:00以及16:00至17:00采集血样。血浆脱氢表雄酮、硫酸脱氢表雄酮、睾酮、双氢睾酮和雌二醇水平未发现显著的统计学变化。素食组的性激素结合球蛋白（SHBG）水平较高，而该组的游离雄激素指数（FAI；通过睾酮/SHBG比值计算）较低。尽管素食组的雄酮葡萄糖醛酸苷浓度较高，但素食者的3α,17β-雄烷二醇葡萄糖醛酸苷和3β,17β-雄烷二醇葡萄糖醛酸苷水平低25 - 50%。我们的数据进一步表明，3α,17β-雄烷二醇葡萄糖醛酸苷和3β,17β-雄烷二醇葡萄糖醛酸苷浓度均与SHBG水平和FAI值显著相关。杂食组中3α,17β-雄烷二醇葡萄糖醛酸苷和3β,17β-雄烷二醇葡萄糖醛酸苷水平的升高可能是FAI升高的结果。我们的数据表明，在素食组中，可用于雄激素作用的睾酮较少。
