欧洲和美国硬蜱中宫本疏螺旋体的流行情况。
Prevalence of Borrelia miyamotoi in Ixodes ticks in Europe and the United States.
作者信息
Crowder Chris D, Carolan Heather E, Rounds Megan A, Honig Vaclav, Mothes Benedikt, Haag Heike, Nolte Oliver, Luft Ben J, Grubhoffer Libor, Ecker David J, Schutzer Steven E, Eshoo Mark W
出版信息
Emerg Infect Dis. 2014 Oct;20(10):1678-82. doi: 10.3201/eid2010.131583.
Abstract
Borrelia miyamotoi, a relapsing fever-related spirochete transmitted by Ixodes ticks, has been recently shown to be a human pathogen. To characterize the prevalence of this organism in questing Ixodes ticks, we tested 2,754 ticks for a variety of tickborne pathogens by PCR and electrospray-ionization mass spectrometry. Ticks were collected from California, New York, Connecticut, Pennsylvania, and Indiana in the United States and from Germany and the Czech Republic in Europe from 2008 through 2012. In addition, an isolate from Japan was characterized. We found 3 distinct genotypes, 1 for North America, 1 for Europe, and 1 for Japan. We found B. miyamotoi infection in ticks in 16 of the 26 sites surveyed, with infection prevalence as high as 15.4%. These results show the widespread distribution of the pathogen, indicating an exposure risk to humans in areas where Ixodes ticks reside.
摘要
伯氏疏螺旋体（Borrelia miyamotoi）是一种通过硬蜱传播的与回归热相关的螺旋体，最近已被证明是一种人类病原体。为了确定这种微生物在觅食硬蜱中的流行情况，我们通过聚合酶链反应（PCR）和电喷雾电离质谱法对2754只蜱进行了多种蜱传病原体检测。蜱于2008年至2012年期间在美国的加利福尼亚州、纽约州、康涅狄格州、宾夕法尼亚州和印第安纳州以及欧洲的德国和捷克共和国采集。此外，对一株来自日本的分离株进行了特征分析。我们发现了3种不同的基因型，1种来自北美，1种来自欧洲，1种来自日本。在调查的26个地点中的16个地点的蜱中发现了伯氏疏螺旋体感染，感染率高达15.4%。这些结果表明该病原体分布广泛，提示在硬蜱栖息地区人类存在接触风险。
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