Department of Physics, Lomonosov Moscow State University, 119991, Moscow, Russia.
Leibniz Institute of Photonic Technology, Jena 07745, Germany.
Nanoscale Res Lett. 2014 Sep 3;9(1):463. doi: 10.1186/1556-276X-9-463. eCollection 2014.
Evaluation of cytotoxicity, photoluminescence, bio-imaging, and sonosensitizing properties of silicon nanoparticles (SiNPs) prepared by ultrasound grinding of porous silicon nanowires (SiNWs) have been investigated. SiNWs were formed by metal (silver)-assisted wet chemical etching of heavily boron-doped (100)-oriented single crystalline silicon wafers. The prepared SiNWs and aqueous suspensions of SiNPs exhibit efficient room temperature photoluminescence (PL) in the spectral region of 600 to 1,000 nm that is explained by the radiative recombination of excitons confined in small silicon nanocrystals, from which SiNWs and SiNPs consist of. On the one hand, in vitro studies have demonstrated low cytotoxicity of SiNPs and possibilities of their bio-imaging applications. On the other hand, it has been found that SiNPs can act as efficient sensitizers of ultrasound-induced suppression of the viability of Hep-2 cancer cells.
研究了通过超声研磨多孔硅纳米线（SiNWs）制备的硅纳米颗粒（SiNPs）的细胞毒性、光致发光、生物成像和超声敏化性能。SiNWs 是通过金属（银）辅助的重掺硼（100）取向单晶硅片的湿法化学刻蚀形成的。所制备的 SiNWs 和 SiNPs 的水悬浮液在 600 至 1000nm 的光谱区域表现出高效的室温光致发光（PL），这可以解释为束缚在小硅纳米晶体中的激子的辐射复合，SiNWs 和 SiNPs 就是由这些小硅纳米晶体组成的。一方面，体外研究表明 SiNPs 的细胞毒性低，并且具有生物成像应用的可能性。另一方面，已经发现 SiNPs 可以作为超声诱导抑制 Hep-2 癌细胞活力的有效敏化剂。
