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经过阳极氧化、循环预钙化和热处理的Ti6Al4V合金正畸微螺钉的相容性增强及初始稳定性提高。

Enhanced compatibility and initial stability of Ti6Al4V alloy orthodontic miniscrews subjected to anodization, cyclic precalcification, and heat treatment.

作者信息

Oh Eun-Ju, Nguyen Thuy-Duong T, Lee Seung-Youp, Jeon Young-Mi, Bae Tae-Sung, Kim Jong-Gee

机构信息

Sun Dental Hospital, Daejeon, Korea.

Department of Dental Biomaterials and Institute of Oral Bioscience, Brain Korea 21 Project, School of Dentistry, Chonbuk National University, Jeonju, Korea.

出版信息

Korean J Orthod. 2014 Sep;44(5):246-53. doi: 10.4041/kjod.2014.44.5.246. Epub 2014 Sep 25.

DOI:10.4041/kjod.2014.44.5.246
PMID:25309864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4192526/
Abstract

OBJECTIVE

To evaluate the bioactivity, and the biomechanical and bone-regenerative properties of Ti6Al4V miniscrews subjected to anodization, cyclic precalcification, and heat treatment (APH treatment) and their potential clinical use.

METHODS

The surfaces of Ti6Al4V alloys were modified by APH treatment. Bioactivity was assessed after immersion in simulated body fluid for 3 days. The hydrophilicity and the roughness of APH-treated surfaces were compared with those of untreated (UT) and anodized and heat-treated (AH) samples. For in vivo tests, 32 miniscrews (16 UT and 16 APH) were inserted into 16 Wistar rats, one UT and one APH-treated miniscrew in either tibia. The miniscrews were extracted after 3 and 6 weeks and their osseointegration (n = 8 for each time point and group) was investigated by surface and histological analyses and removal torque measurements.

RESULTS

APH treatment formed a dense surface array of nanotubular TiO2 layer covered with a compact apatite-like film. APH-treated samples showed better bioactivity and biocompatibility compared with UT and AH samples. In vivo, APH-treated miniscrews showed higher removal torque and bone-to-implant contact than did UT miniscrews, after both 3 and 6 weeks (p < 0.05). Also, early deposition of densely mineralized bone around APH-treated miniscrews was observed, implying good bonding to the treated surface.

CONCLUSIONS

APH treatment enhanced the bioactivity, and the biomechanical and bone regenerative properties of the Ti6Al4V alloy miniscrews. The enhanced initial stability afforded should be valuable in orthodontic applications.

摘要

目的

评估经过阳极氧化、循环预钙化和热处理(APH处理)的Ti6Al4V微型螺钉的生物活性、生物力学和骨再生特性及其潜在的临床应用价值。

方法

采用APH处理对Ti6Al4V合金表面进行改性。将样品浸泡在模拟体液中3天后评估其生物活性。将经过APH处理的表面的亲水性和粗糙度与未处理(UT)以及经过阳极氧化和热处理(AH)的样品进行比较。对于体内试验,将32枚微型螺钉(16枚UT和16枚APH)植入16只Wistar大鼠体内,每只胫骨中植入一枚UT和一枚APH处理的微型螺钉。在3周和6周后取出微型螺钉,通过表面和组织学分析以及去除扭矩测量来研究其骨整合情况(每个时间点和组n = 8)。

结果

APH处理形成了一层致密的纳米管状TiO2表面阵列,上面覆盖着一层致密的类磷灰石薄膜。与UT和AH样品相比,经过APH处理的样品表现出更好的生物活性和生物相容性。在体内,经过APH处理的微型螺钉在3周和6周后均显示出比UT微型螺钉更高的去除扭矩和骨与种植体接触率(p < 0.05)。此外,观察到在经过APH处理的微型螺钉周围早期有密集矿化骨的沉积,这意味着与处理过的表面有良好的结合。

结论

APH处理增强了Ti6Al4V合金微型螺钉的生物活性、生物力学和骨再生特性。所提供的增强的初始稳定性在正畸应用中应具有重要价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3534/4192526/4c030658e096/kjod-44-246-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3534/4192526/5a0ddb010f7b/kjod-44-246-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3534/4192526/64ad509dd6ae/kjod-44-246-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3534/4192526/e465bb610478/kjod-44-246-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3534/4192526/0a789bb4f407/kjod-44-246-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3534/4192526/3cb5423f358f/kjod-44-246-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3534/4192526/4c030658e096/kjod-44-246-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3534/4192526/5a0ddb010f7b/kjod-44-246-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3534/4192526/64ad509dd6ae/kjod-44-246-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3534/4192526/e465bb610478/kjod-44-246-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3534/4192526/0a789bb4f407/kjod-44-246-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3534/4192526/3cb5423f358f/kjod-44-246-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3534/4192526/4c030658e096/kjod-44-246-g006.jpg

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