Mastropasqua Leonardo, Calienno Roberta, Lanzini Manuela, Colasante Martina, Mastropasqua Alessandra, Mattei Peter A, Nubile Mario
Ophthalmic Clinic, University "G d'Annunzio" of Chieti-Pescara, Via dei Vestini, 66100 Chieti, Italy.
Ophthalmic Clinic, Campus Biomedico, University of Rome, 00185 Rome, Italy.
Biomed Res Int. 2014;2014:290619. doi: 10.1155/2014/290619. Epub 2014 Aug 31.
To quantify the effect of small incision lenticule extraction (SMILE) on the corneal biomechanics using Scheimpflug noncontact tonometer (Corvis ST).
Twenty eyes of twenty patients, evaluated as eligible for surgery, with high myopia and/or moderate myopic astigmatism, underwent small incision lenticule extraction (SMILE). All patients underwent Corvis ST preoperatively and postoperatively after 1 week, and 1 and 3 months to observe alterations of corneal biomechanical properties. The main outcome measures were Deformation Amplitude, 1st-AT, and 2nd-AT. The relationship between the amount of stroma removed and the percentage variation of the measured parameters from baseline was evaluated with generalized linear model from each time point. For completeness also intraocular pressure (IOP), central corneal thickness (CCT), and their variations after surgery were evaluated.
The ratio between the amount of removed refractive error and, respectively, changes of Deformation Amplitude, 1st-AT, and 2nd-AT were significantly modified at the 1st week after surgery (P = 0.005; P = 0.001; P = 0.024). At 1 and 3 months these values did not show statistically significant alterations. Intraocular pressure and central corneal thickness showed statistically significant changes during follow-up.
No significant modifications in biomechanical properties were observed after SMILE so this procedure could induce only minimal transient alterations of corneal biomechanics.
使用Scheimpflug非接触眼压计(Corvis ST)量化小切口透镜切除术(SMILE)对角膜生物力学的影响。
20例符合手术条件的高度近视和/或中度近视散光患者的20只眼睛接受了小切口透镜切除术(SMILE)。所有患者在术前以及术后1周、1个月和3个月接受Corvis ST检查,以观察角膜生物力学特性的变化。主要观察指标为变形幅度、第一次到达时间(1st-AT)和第二次到达时间(2nd-AT)。从每个时间点使用广义线性模型评估切除的基质量与测量参数相对于基线的百分比变化之间的关系。为了全面起见,还评估了眼压(IOP)、中央角膜厚度(CCT)及其术后变化。
术后第1周,去除的屈光不正量与变形幅度、1st-AT和2nd-AT变化之间的比率有显著改变(P = 0.005;P = 0.001;P = 0.024)。在1个月和3个月时,这些值未显示出统计学上的显著变化。随访期间眼压和中央角膜厚度显示出统计学上的显著变化。
SMILE术后未观察到生物力学特性的显著改变,因此该手术可能仅引起角膜生物力学的最小短暂改变。