Chan Thomas Y K
Division of Clinical Pharmacology and Drug and Poisons Information Bureau, Department of Medicine and Therapeutics, Faculty of Medicine, the Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, China.
Toxins (Basel). 2014 Oct 20;6(10):2989-97. doi: 10.3390/toxins6102989.
In the present review, the main objective was to describe the epidemiology and clinical features of ciguatera fish poisoning in Hong Kong. From 1989 to 2008, the annual incidence of ciguatera varied between 3.3 and 64.9 (median 10.2) per million people. The groupers have replaced the snappers as the most important cause of ciguatera. Pacific-ciguatoxins (CTX) are most commonly present in reef fish samples implicated in ciguatera outbreaks. In affected subjects, the gastrointestinal symptoms often subside within days, whereas the neurological symptoms can persist for weeks or even months. Bradycardia and hypotension, which can be life-threatening, are common. Treatment of ciguatera is primarily supportive and symptomatic. Intravenous mannitol (1 g/kg) has also been suggested. To prevent ciguatera outbreaks, the public should be educated to avoid eating large coral reef fishes, especially the CTX-rich parts. A Code of Practice on Import and Sale of Live Marine Fish for Human Consumption for Prevention and Control of Ciguatera Fish Poisoning was introduced from 2004 to 2013. The Food Safety Ordinance with a tracing mechanism came into full effect in February 2012. The Government would be able to trace the sources of the fishes more effectively and take prompt action when dealing with ciguatera incidents.
在本综述中,主要目的是描述香港雪卡毒素中毒的流行病学和临床特征。1989年至2008年期间,雪卡毒素中毒的年发病率为每百万人3.3至64.9例(中位数为10.2例)。石斑鱼已取代笛鲷成为雪卡毒素中毒的最重要病因。太平洋雪卡毒素(CTX)最常出现在与雪卡毒素中毒事件相关的珊瑚礁鱼类样本中。在受影响的个体中,胃肠道症状通常在数天内消退,而神经症状可能持续数周甚至数月。心动过缓和低血压很常见,可能危及生命。雪卡毒素中毒的治疗主要是支持性和对症治疗。也有人建议静脉注射甘露醇(1 g/kg)。为防止雪卡毒素中毒事件的爆发,应教育公众避免食用大型珊瑚礁鱼类,尤其是富含CTX的部位。2004年至2013年期间出台了《供人类食用的活海鱼进口及销售预防和控制雪卡毒素中毒操作规范》。2012年2月,带有追溯机制的《食品安全条例》全面生效。政府将能够更有效地追踪鱼类来源,并在处理雪卡毒素中毒事件时迅速采取行动。