Bressan Eriberto, Ferroni Letizia, Gardin Chiara, Sbricoli Luca, Gobbato Luca, Ludovichetti Francesco Saverio, Tocco Ilaria, Carraro Amedeo, Piattelli Adriano, Zavan Barbara
Department of Neurosciences, University of Padova, via Giustiniani 2, 35131, Padova, Italy.
Department of Biomedical Sciences, University of Padova, via Giuseppe Colombo 3, 35131, Padova, Italy.
J Transl Med. 2014 Oct 25;12:296. doi: 10.1186/s12967-014-0296-9.
Graphene is a flat monolayer of carbon atoms, arranged in a two-dimensional hexagonal structure, with extraordinary electrical, thermal, and physical properties. Moreover, the molecular structure of graphene can be chemically modified with molecules of interest to promote the development of high-performance devices. Although carbon derivatives have been extensively employed in industry and electronics, their use in regenerative medicine is still in an early phase. Study prove that graphene is highly biocompatible, has low toxicity and a large dosage loading capacity. This review describes the ability of graphene and its related materials to induce stem cells differentiation into osteogenic, neuronal, and adipogenic lineages.
石墨烯是由碳原子构成的单层扁平结构，呈二维六边形排列，具有卓越的电学、热学和物理性质。此外，石墨烯的分子结构可以通过与感兴趣的分子进行化学修饰，以促进高性能器件的发展。尽管碳衍生物已在工业和电子领域广泛应用，但其在再生医学中的应用仍处于早期阶段。研究证明，石墨烯具有高度的生物相容性、低毒性和大剂量负载能力。本文综述了石墨烯及其相关材料诱导干细胞分化为成骨、神经元和脂肪生成谱系的能力。
