Bacaita E S, Ciobanu B C, Popa M, Agop M, Desbrieres J
Department of Physics, "Gheorghe Asachi" Technical University of Iasi, Prof. Dr. docent Dimitrie Mangeron Rd., No. 73, Iasi 700050, Romania.
Phys Chem Chem Phys. 2014 Dec 21;16(47):25896-905. doi: 10.1039/c4cp03389b. Epub 2014 Oct 30.
The study proposes modeling calcein release kinetics (considered as a hydrophilic drug model) from an interpenetrating network matrix of hydrogels, based on the combination of two polymers, of which chitosan is the most commonly used polymer. The release process is analyzed for different increasing time intervals, based on the evolution of the release kinetics. For each time interval, a dominant release mechanism was identified and quantitative analyses were performed, to probe the existence of four distinct stages during its evolution with each stage governed by a different kinetics model. An interesting and original aspect, which is analyzed through a novel approach, is that of drug release at longer time scales, which is often overlooked. It revealed that the system behaves as a complex one and its evolution can be described through a nonlinear theoretical model, which offers us new insights into its order-disorder evolution.
该研究提出了一种基于两种聚合物（其中壳聚糖是最常用的聚合物）组合的互穿网络水凝胶基质中钙黄绿素释放动力学（被视为亲水性药物模型）的建模方法。基于释放动力学的演变，对不同增加的时间间隔的释放过程进行了分析。对于每个时间间隔，确定了主要的释放机制并进行了定量分析，以探究其演变过程中四个不同阶段的存在，每个阶段由不同的动力学模型控制。通过一种新颖的方法分析的一个有趣且新颖的方面是较长时间尺度下的药物释放，这一点常常被忽视。结果表明，该系统表现为一个复杂系统，其演变可以通过非线性理论模型来描述，这为我们提供了关于其有序-无序演变的新见解。
