Peptu Cătălina Anișoara, Băcăiță Elena Simona, Savin Logigan Corina-Lenuta, Luțcanu Marian, Agop Maricel
Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection, "Gheorghe Asachi" Technical University of Iasi, 71, Prof. Dr. Docent DimitrieMangeron Street, 700050 Iasi, Romania.
Department of Physics, Faculty of Machine Manufacturing and Industrial Management, "Gheorghe Asachi" Technical University of Iasi, Bd. Prof. Dr. Docent Dimitrie Mangeron73, 700050 Iasi, Romania.
Polymers (Basel). 2021 Dec 20;13(24):4461. doi: 10.3390/polym13244461.
New hydrogels films crosslinked with epichlorohydrin were prepared based on alginates and carboxymethyl cellulose with properties that recommend them as potential drug delivery systems (e.g., biocompatibility, low toxicity, non-immunogenicity, hemostatic activity and the ability to absorb large amounts of water). The characterization of their structural, morphological, swelling capacity, loading/release and drug efficiency traits proved that these new hydrogels are promising materials for controlled drug delivery systems. Further, a new theoretical model, in the framework of Scale Relativity Theory, was built with to offer insights on the release process at the microscopic level and to simplify the analysis of the release process.
基于藻酸盐和羧甲基纤维素制备了与环氧氯丙烷交联的新型水凝胶薄膜，其特性使其有望成为潜在的药物递送系统（例如，生物相容性、低毒性、非免疫原性、止血活性以及吸收大量水分的能力）。对其结构、形态、溶胀能力、负载/释放及药物效率特性的表征证明，这些新型水凝胶是用于控释药物递送系统的有前景的材料。此外，在标度相对论理论框架内建立了一个新的理论模型，以提供微观层面释放过程的见解并简化对释放过程的分析。
