Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Department of Neurology, Korea University College of Medicine, Seoul, Korea.
J Mov Disord. 2014 Oct;7(2):84-91. doi: 10.14802/jmd.14012. Epub 2014 Oct 30.
Stem cell treatment is a well-recognized experimental treatment among patients with Parkinson's disease (PD), for which there are high expectations of a positive impact. Acupuncture with bee venom is one of the most popular complementary and alternative treatments for PD. Patient knowledge and attitudes towards these experimental treatments are unknown.
Using a 12-item questionnaire, a nationwide survey was conducted of 963 PD patients and 267 caregivers in 44 Korean Movement Disorders Society member hospitals from April 2013 to June 2013. The survey was performed by trained interviewers using conventional methods.
Regarding questions on experimental treatments using stem cells or bee venom acupuncture, 5.1-17.7% of PD patients answered questions on safety, efficacy, and evidence-based practice incorrectly; however, more than half responded that they did not know the correct answer. Although safety and efficacy have not been established, 55.5% of PD patients responded that they were willing to receive stem cell treatment. With regard to participating in experimental treatments, there was a strong correlation between stem cell treatment and bee venom acupuncture (p < 0.0001, odds ratio = 5.226, 95% confidence interval 3.919-6.969). Younger age, higher education, and a longer duration of PD were all associated with a correct understanding of experimental treatments.
Our data suggest that relatively few PD patients correctly understand the safety and efficacy of experimental treatments and that PD patients are greatly interested in new treatments. We hope that our data will be used to educate or to plan educational programs for PD patients and caregivers.
干细胞治疗是帕金森病（PD）患者公认的实验性治疗方法，人们对其有很高的积极影响的期望。蜂毒针灸是 PD 最受欢迎的补充和替代疗法之一。患者对这些实验性治疗的了解和态度尚不清楚。
2013 年 4 月至 6 月，采用 12 项问卷对来自 44 家韩国运动障碍学会成员医院的 963 名 PD 患者和 267 名护理人员进行了全国范围的调查。调查由经过培训的访谈员使用常规方法进行。
对于使用干细胞或蜂毒针灸的实验性治疗的问题，5.1%-17.7%的 PD 患者对安全性、有效性和循证实践的回答不正确；然而，超过一半的人回答说他们不知道正确答案。尽管安全性和有效性尚未确立，但 55.5%的 PD 患者表示愿意接受干细胞治疗。对于参与实验性治疗，干细胞治疗与蜂毒针灸之间存在很强的相关性（p<0.0001，优势比=5.226，95%置信区间 3.919-6.969）。年龄较小、受教育程度较高和 PD 持续时间较长均与对实验性治疗的正确理解相关。
我们的数据表明，相对较少的 PD 患者正确理解实验性治疗的安全性和有效性，且 PD 患者对新的治疗方法非常感兴趣。我们希望我们的数据将被用于教育 PD 患者和护理人员，或用于计划教育项目。
