惰性气体作为心脏保护剂——可译性与作用机制
Noble gases as cardioprotectants - translatability and mechanism.
作者信息
Smit Kirsten F, Weber Nina C, Hollmann Markus W, Preckel Benedikt
机构信息
Department of Anaesthesiology, Laboratory of Experimental Intensive Care and Anaesthesiology (L.E.I.C.A), Academic Medical Centre (AMC), Amsterdam, The Netherlands.
出版信息
Br J Pharmacol. 2015 Apr;172(8):2062-73. doi: 10.1111/bph.12994. Epub 2015 Jan 12.
Abstract
Several noble gases, although classified as inert substances, exert a tissue-protective effect in different experimental models when applied before organ ischaemia as an early or late preconditioning stimulus, after ischaemia as a post-conditioning stimulus or when given in combination before, during and/or after ischaemia. A wide range of organs can be protected by these inert substances, in particular cardiac and neuronal tissue. In this review we summarize the data on noble gas-induced cardioprotection, focusing on the underlying protective mechanisms. We will also look at translatability of experimental data to the clinical situation.
摘要
几种稀有气体，尽管被归类为惰性物质，但在器官缺血前作为早期或晚期预处理刺激应用时、缺血后作为后处理刺激应用时，或在缺血前、期间和/或之后联合给予时，在不同的实验模型中发挥组织保护作用。这些惰性物质可以保护多种器官，特别是心脏和神经组织。在本综述中，我们总结了关于稀有气体诱导心脏保护的数据，重点关注潜在的保护机制。我们还将探讨实验数据向临床情况的可转化性。
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1
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2
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