Murase Kimihiko, Tabara Yasuharu, Takahashi Yoshimitsu, Muro Shigeo, Yamada Ryo, Setoh Kazuya, Kawaguchi Takahisa, Kadotani Hiroshi, Kosugi Shinji, Sekine Akihiro, Nakayama Takeo, Mishima Michiaki, Chiba Tsutomu, Chin Kazuo, Matsuda Fumihiko
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Sleep. 2014 Nov 1;37(11):1809-15. doi: 10.5665/sleep.4176.
STUDY OBJECTIVES: To examine relationships among gastroesophageal reflux disease (GERD) symptoms, dietary behaviors, and sleep duration in the general population. DESIGN: Cross-sectional. SETTING: Community-based. PARTICIPANTS: There were 9,643 participants selected from the general population (54 ± 13 y). INTERVENTIONS: None. MEASUREMENTS AND RESULTS: Sleep duration, sleep habits, and unfavorable dietary behaviors of each participant were assessed with a structured questionnaire. Participants were categorized into five groups according to their sleep duration: less than 5 h, 5 to less than 6 h, 6 to less than 7 h, 7 to less than 8 h, and 8 or more h per day. GERD was evaluated using the Frequency Scale for the Symptoms of GERD (FSSG) and participants having an FSSG score of 8 or more or those under treatment of GERD were defined as having GERD. Trend analysis showed that both the FSSG score and the number of unfavorable dietary habits increased with decreasing sleep duration. Further, multiple logistic regression analysis showed that both the presence of GERD (odds ratio = 1.19, 95% confidence interval (CI) = 1.07-1.32) and the number of unfavorable dietary behaviors (odds ratio = 1.19, 95% CI = 1.13-1.26) were independent and potent factors to identify participants with short sleep duration even after controlling for other confounding factors. CONCLUSION: The current study showed that both GERD symptoms and unfavorable dietary behaviors were significant correlates of short sleep duration independently of each other in a large sample from the general population.
研究目的：探讨普通人群中胃食管反流病（GERD）症状、饮食行为和睡眠时间之间的关系。 设计：横断面研究。 地点：基于社区。 参与者：从普通人群中选取9643名参与者（年龄54±13岁）。 干预措施：无。 测量与结果：通过结构化问卷评估每位参与者的睡眠时间、睡眠习惯和不良饮食行为。根据睡眠时间将参与者分为五组：每天少于5小时、5至少于6小时、6至少于7小时、7至少于8小时以及8小时或更长时间。使用胃食管反流病症状频率量表（FSSG）评估GERD，FSSG得分8分或更高或正在接受GERD治疗的参与者被定义为患有GERD。趋势分析表明，FSSG得分和不良饮食习惯的数量均随睡眠时间的减少而增加。此外，多因素logistic回归分析表明，即使在控制其他混杂因素后，GERD的存在（比值比=1.19，95%置信区间（CI）=1.07 - 1.32）和不良饮食行为的数量（比值比=1.19，95%CI = 1.13 - 1.26）都是识别睡眠时间短的参与者的独立且有力的因素。 结论：当前研究表明，在来自普通人群的大样本中，GERD症状和不良饮食行为均是睡眠时间短的显著相关因素，且二者相互独立。
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