Khoshzaban Fariba, Ghaffarifar Fatemeh, Jamshidi Koohsari Hamid Reza
Department of Parasitology and Mycology, Faculty of Medical Sciences, Shahed University, Tehran, IR Iran.
Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IR Iran.
Jundishapur J Microbiol. 2014 Jul;7(7):e10992. doi: 10.5812/jjm.10992. Epub 2014 Jul 1.
Leishmaniasis is one of the six most common parasitic infections in the tropical regions. There are different therapeutic modalities, however therapeutic resistance is developed and resulted in numerous problems. Therefore, evaluation of other therapeutic modalities is performed extensively.
The current study aimed to compare the therapeutic response of cutaneous leishmaniasis with Glucantime and Peganum harmala extracts (aqueous and ethanol) in the animal model.
The therapeutic response of Leishmania major to Glucantime and P. harmala extracts (aqueous and ethanol) in animal model was studied in BALB/c mice. These mice were divided into four groups according to receiving either one of these three agents, and the control group. The therapeutic response was evaluated according to the parasitic load before and after treatment and also with measuring the size of the lesions.
The results showed that ethanol extract of P. harmala had good therapeutic efficacy in treatment of lesions in mice (P < 0.05), and the efficacy was significant in the eighth week after the treatment. There was also a statistically significant difference between the groups regarding the parasitic load (P < 0.05).
According to the current study results, it may be concluded that ethanol extract of P. harmala is efficient in the treatment of cutaneous leishmaniasis, and the efficiency is comparable with that of Glucantime.
利什曼病是热带地区六种最常见的寄生虫感染之一。存在不同的治疗方式，然而治疗耐药性产生并导致了许多问题。因此，广泛开展了对其他治疗方式的评估。
本研究旨在比较葡糖胺锑和骆驼蓬提取物（水提取物和乙醇提取物）在动物模型中对皮肤利什曼病的治疗反应。
在BALB/c小鼠中研究了硕大利什曼原虫对葡糖胺锑和骆驼蓬提取物（水提取物和乙醇提取物）在动物模型中的治疗反应。这些小鼠根据接受这三种药物之一或作为对照组被分为四组。根据治疗前后的寄生虫负荷以及测量病变大小来评估治疗反应。
结果显示，骆驼蓬乙醇提取物在治疗小鼠病变方面具有良好的疗效（P < 0.05），且在治疗后第八周疗效显著。各组之间在寄生虫负荷方面也存在统计学显著差异（P < 0.05）。
根据本研究结果，可以得出结论，骆驼蓬乙醇提取物在治疗皮肤利什曼病方面有效，且疗效与葡糖胺锑相当。
