Simmons A
Division of Medical Virology, Institute of Medical and Veterinary Science, Adelaide, Australia.
J Exp Med. 1989 Apr 1;169(4):1503-7. doi: 10.1084/jem.169.4.1503.
Infection of the peripheral nervous system was studied after inoculation of HSV into the flank skin of H-2 congenic mice. The amount of virus recovered from the sensory ganglia varied significantly between the mouse strains tested. Differences became apparent 7 d after infection, at which time the severity of disease in H-2k mice was two to three orders of magnitude greater than that in H-2d animals. The association of the H-2k haplotype with impaired ability to clear HSV from the nervous system is the first clear demonstration that genes within the MHC can influence the severity of primary herpetic infection, in spite of numerous studies on genetic resistance to this disease.
将单纯疱疹病毒（HSV）接种到H-2同源基因小鼠的胁腹皮肤后，对其外周神经系统感染情况进行了研究。在所测试的小鼠品系中，从感觉神经节中回收的病毒量有显著差异。感染后7天差异变得明显，此时H-2k小鼠的疾病严重程度比H-2d动物高两到三个数量级。H-2k单倍型与从神经系统清除HSV的能力受损之间的关联首次明确表明，尽管对这种疾病的遗传抗性进行了大量研究，但主要组织相容性复合体（MHC）内的基因可以影响原发性疱疹感染的严重程度。
