Andreoli Michael T, Aakalu Vinay, Setabutr Pete
Illinois Eye and Ear Infirmary, UIC Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago, Illinois, USA
Illinois Eye and Ear Infirmary, UIC Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago, Illinois, USA.
Otolaryngol Head Neck Surg. 2015 Feb;152(2):279-83. doi: 10.1177/0194599814556624. Epub 2014 Nov 10.
To describe epidemiological trends in lacrimal gland malignancies in the United States.
Retrospective database review.
Multicenter registry.
A total of 702 malignant tumors of the lacrimal gland from the Surveillance, Epidemiology, and End Results database were included in the study. Disease-specific and overall survival were the primary outcome measures. Kaplan-Meier survival curves were generated for multiple patient and tumor characteristics, including race, histology, TNM tumor stage, age at diagnosis, radiotherapy, gender, and tumor grade. Cox proportional hazards regression was performed to assess the impact of patient and tumor characteristics on survival.
Lymphoma (58.0%), adenoid cystic carcinoma (13.4%), adenocarcinoma (3.8%), and mucoepidermoid carcinoma (3.6%) accounted for most tumors. Lymphoma was associated with more favorable survival rates, while adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma were associated with worse prognosis. There was a steady increase in the proportion of lymphoma diagnosed since 1973. In a multivariate Cox proportional hazards regression model, tumor histology remained as the only covariate correlated with disease-specific survival.
Patient characteristics and survival rates differ between lymphoma, adenoid cystic carcinoma, adenocarcinoma, and mucoepidermoid carcinoma. The proportion of lacrimal gland cancer diagnosed as lymphoma has steadily increased over time. Cox proportional hazards regression analysis demonstrated tumor histology as one of the most important factors in patient survival. These results augment our understanding of the expected disease course of lacrimal gland malignancies.
描述美国泪腺恶性肿瘤的流行病学趋势。
回顾性数据库分析。
多中心登记处。
本研究纳入了监测、流行病学和最终结果数据库中702例泪腺恶性肿瘤。疾病特异性生存率和总生存率是主要观察指标。针对多种患者和肿瘤特征绘制了Kaplan-Meier生存曲线，这些特征包括种族、组织学类型、TNM肿瘤分期、诊断时年龄、放疗情况、性别和肿瘤分级。采用Cox比例风险回归分析评估患者和肿瘤特征对生存的影响。
淋巴瘤（58.0%）、腺样囊性癌（13.4%）、腺癌（3.8%）和黏液表皮样癌（3.6%）占大多数肿瘤。淋巴瘤的生存率较高，而腺癌、腺样囊性癌和黏液表皮样癌的预后较差。自1973年以来，诊断为淋巴瘤的比例稳步上升。在多变量Cox比例风险回归模型中，肿瘤组织学类型仍然是与疾病特异性生存相关的唯一协变量。
淋巴瘤、腺样囊性癌、腺癌和黏液表皮样癌的患者特征和生存率存在差异。随着时间的推移，诊断为淋巴瘤的泪腺癌比例稳步增加。Cox比例风险回归分析表明肿瘤组织学类型是影响患者生存的最重要因素之一。这些结果加深了我们对泪腺恶性肿瘤预期病程的理解。
