Shroff Anjali, Mamalis Andrew, Jagdeo Jared
Department of Dermatology, Icahn School of Medicine at Mount Sinai, Clinical Research - Dermatology, 5 East 98th Street- 5th floor, Box 1048, New York, NY USA.
Department of Dermatology, University of California Davis, Sacramento, CA USA ; Dermatology Service, Sacramento VA Medical Center, Mather, CA USA.
Curr Pathobiol Rep. 2014;2(4):257-267. doi: 10.1007/s40139-014-0062-y.
Fibrosis is defined as increased fibroblast proliferation and deposition of extracellular matrix components with potential clinical ramifications including organ dysfunction and failure. Fibrosis is a characteristic finding of various skin diseases which can have life-threatening consequences. These implications call for research into this topic as only a few treatments targeting fibrosis are available. In this review, we discuss oxidative stress and its role in skin fibrosis. Recent studies have implicated the importance of oxidative stress in a variety of cellular pathways directly and indirectly involved in the pathogenesis of skin fibrosis. The cellular pathways by which oxidative stress affects specific fibrotic skin disorders are also reviewed. Finally, we also describe various therapeutic approaches specifically targeting oxidative stress to prevent skin fibrosis. We believe oxidative stress is a relevant target, and understanding the role of oxidative stress in skin fibrosis will enhance knowledge of fibrotic skin diseases and potentially produce targeted therapeutic options.
纤维化的定义为成纤维细胞增殖增加以及细胞外基质成分的沉积，其具有潜在的临床后果，包括器官功能障碍和衰竭。纤维化是各种皮肤疾病的一个特征性表现，可能会产生危及生命的后果。由于针对纤维化的治疗方法有限，这些影响促使人们对该主题进行研究。在本综述中，我们讨论氧化应激及其在皮肤纤维化中的作用。最近的研究表明，氧化应激在直接和间接参与皮肤纤维化发病机制的各种细胞途径中具有重要意义。本文还综述了氧化应激影响特定纤维化皮肤疾病的细胞途径。最后，我们还描述了专门针对氧化应激以预防皮肤纤维化的各种治疗方法。我们认为氧化应激是一个相关靶点，了解氧化应激在皮肤纤维化中的作用将增进对纤维化皮肤疾病的认识，并可能产生有针对性的治疗选择。
