Boberg M, Vessby B, Selinus I
Acta Med Scand. 1986;220(2):153-60. doi: 10.1111/j.0954-6820.1986.tb02743.x.
Twenty-seven patients with hypertriglyceridaemia were given dietary supplementation either with evening primrose oil rich in gammalinolenic acid (GLA, 18:3 n-6) (n = 13) or a marine oil concentrate containing n-3 fatty acids (n = 14) in a double-blind cross-over design during 8 + 8 weeks with olive oil as placebo. During GLA supplementation, increases in GLA and dihomogammalinolenic acid (20:3 n-6) were found in plasma lipid esters and platelet phospholipids, whereas platelet function and serum lipoproteins were unaffected. During supplementation with n-3 fatty acids there was a significant decrease in triglycerides in all lipoprotein fractions with a slight increase in high density lipoprotein and low density lipoprotein cholesterol. A marked increase in the long-chain n-3 fatty acids was found both in plasma and platelets, mainly at the expense of the n-6 fatty acids. No pronounced effects on platelet reactivity could be demonstrated. Our results confirm a triglyceride-lowering effect of n-3 fatty acids, whereas no such effect of GLA could be demonstrated.
27名高甘油三酯血症患者参与了一项双盲交叉试验，在8 + 8周的时间里，一组（n = 13）给予富含γ-亚麻酸（GLA，18:3 n-6）的月见草油进行饮食补充，另一组（n = 14）给予含n-3脂肪酸的海洋油浓缩物，以橄榄油作为安慰剂。在补充GLA期间，血浆脂质酯和血小板磷脂中的GLA和二高γ-亚麻酸（20:3 n-6）含量增加，但血小板功能和血清脂蛋白未受影响。在补充n-3脂肪酸期间，所有脂蛋白组分中的甘油三酯显著降低，高密度脂蛋白和低密度脂蛋白胆固醇略有增加。血浆和血小板中的长链n-3脂肪酸显著增加，主要是以n-6脂肪酸为代价。未发现对血小板反应性有明显影响。我们的结果证实了n-3脂肪酸具有降低甘油三酯的作用，而未证实GLA有此作用。
