Highley Christopher B, Rodell Christopher B, Kim Iris L, Wade Ryan J, Burdick J A
Department of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33 Street, Philadelphia, PA 19104, USA.
J Mater Chem B. 2014;2(46):8110-8115. doi: 10.1039/C4TB00724G.
Aligned nanofibrous substrates can be created by electrospinning, but methods for creating multilamellar structures of aligned fibers are limited. Here, apposed nanofibrous scaffolds with pendant -cyclodextrin (CD) were adhered together by adamantane (Ad) modified hyaluronic acid, exploiting the guest-host interactions of CD and Ad for macroscopic assembly. Stable user-defined multi-layered scaffolds were formed for cell culture or tissue engineering.
排列整齐的纳米纤维基质可通过静电纺丝制备，但制备排列整齐纤维的多层结构的方法有限。在此，利用环糊精（CD）与金刚烷（Ad）的客体-主体相互作用进行宏观组装，将带有侧基β-环糊精的并列纳米纤维支架通过金刚烷修饰的透明质酸粘附在一起。形成了用于细胞培养或组织工程的稳定的用户定义多层支架。
