疫苗对犬类免疫系统的影响。
Effects of vaccines on the canine immune system.
作者信息
Phillips T R, Jensen J L, Rubino M J, Yang W C, Schultz R D
机构信息
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison 53706.
出版信息
Can J Vet Res. 1989 Apr;53(2):154-60.
The effects of several commercially available polyvalent canine vaccines on the immune system of the dog were examined. The results demonstrated that the polyvalent vaccines used in this study significantly suppressed the absolute lymphocyte count and that most of the polyvalent vaccines significantly suppressed lymphocyte response to mitogen, but had no effect on natural effector cell activity, neutrophil chemiluminescence, nor antibody response to canine distemper virus. The individual vaccine components from the polyvalent vaccines when inoculated alone did not significantly suppress the lymphocyte response to mitogen. However, when canine distemper virus was combined with canine adenovirus type 1 or canine adenovirus type 2, significant suppression in lymphocyte responsiveness to mitogen occurred. The results indicate that interactions between canine distemper virus and canine adenovirus type 1 or canine adenovirus type 2 are responsible for the polyvalent vaccine induced suppression of lymphocyte responsiveness.
研究了几种市售多价犬用疫苗对犬免疫系统的影响。结果表明，本研究中使用的多价疫苗显著抑制了绝对淋巴细胞计数，并且大多数多价疫苗显著抑制了淋巴细胞对有丝分裂原的反应，但对天然效应细胞活性、中性粒细胞化学发光以及对犬瘟热病毒的抗体反应没有影响。多价疫苗中的各个疫苗成分单独接种时，并未显著抑制淋巴细胞对有丝分裂原的反应。然而，当犬瘟热病毒与1型犬腺病毒或2型犬腺病毒联合时，淋巴细胞对有丝分裂原的反应性出现显著抑制。结果表明，犬瘟热病毒与1型犬腺病毒或2型犬腺病毒之间的相互作用是多价疫苗诱导淋巴细胞反应性抑制的原因。
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