利用纳米颗粒疗法改善放化疗。
Improving chemoradiotherapy with nanoparticle therapeutics.
作者信息
Eblan Michael Joseph, Wang Andrew Zhuang
机构信息
Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599-7512, USA.
出版信息
Transl Cancer Res. 2013 Aug 1;2(4):320-329. doi: 10.3978/j.issn.2218-676X.2013.08.04.
Abstract
Chemoradiotherapy has been a key treatment paradigm in cancer management. One of the main research objectives in cancer research has been to identify agents and strategies to improve the therapeutic index of chemoradiation. Recent development of nanoparticle (NP)-based chemotherapeutics offers a unique opportunity to improve the delivery of chemotherapy, which can in turn improve chemoradiotherapy's efficacy while lowering toxicity. NP-based chemotherapeutics also possess several characteristics that are well suited for chemoradiotherapy. Therefore, NP chemotherapeutics hold high potential in improving the therapeutic index of chemoradiotherapy. This manuscript reviews the NP properties that are favorable for chemoradiation and the rationale to utilize nanotherapeutics in chemoradiation. This review also discusses the preclinical and clinical data on using NP therapeutics in chemoradiotherapy.
摘要
放化疗一直是癌症治疗的关键模式。癌症研究的主要目标之一是确定提高放化疗治疗指数的药物和策略。基于纳米颗粒（NP）的化疗药物的最新进展为改善化疗药物递送提供了独特机遇，这反过来可以提高放化疗疗效并降低毒性。基于NP的化疗药物还具有一些非常适合放化疗的特性。因此，NP化疗药物在提高放化疗治疗指数方面具有很大潜力。本文综述了有利于放化疗的NP特性以及在放化疗中使用纳米疗法的基本原理。本综述还讨论了在放化疗中使用NP疗法的临床前和临床数据。
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