Ferguson Richard Mathew, Khandhar Amit P, Arami Hamed, Hua Loc, Hovorka Ondrej, Krishnan Kannan M
Biomed Tech (Berl). 2013 Dec;58(6):493-507. doi: 10.1515/bmt-2012-0058.
Magnetic particle imaging (MPI) is an attractive new modality for imaging distributions of iron oxide nanoparticle tracers in vivo. With exceptional contrast, high sensitivity, and good spatial resolution, MPI shows promise for clinical imaging in angiography and oncology. Critically, MPI requires high-quality iron oxide nanoparticle tracers with tailored magnetic and surface properties to achieve its full potential. In this review, we discuss optimizing iron oxide nanoparticles' physical, magnetic, and pharmacokinetic properties for MPI, highlighting results from our recent work in which we demonstrated tailored, biocompatible iron oxide nanoparticle tracers that provided two times better linear spatial resolution and five times better signal-to-noise ratio than Resovist.
磁粒子成像（MPI）是一种用于体内氧化铁纳米颗粒示踪剂分布成像的极具吸引力的新模态。凭借出色的对比度、高灵敏度和良好的空间分辨率，MPI在血管造影和肿瘤学临床成像方面显示出前景。至关重要的是，MPI需要具有定制磁性和表面特性的高质量氧化铁纳米颗粒示踪剂，以充分发挥其潜力。在本综述中，我们讨论了优化用于MPI的氧化铁纳米颗粒的物理、磁性和药代动力学特性，重点介绍了我们近期工作的成果，其中我们展示了定制的、生物相容性氧化铁纳米颗粒示踪剂，其线性空间分辨率比Resovist高两倍，信噪比高五倍。
