CogState计算机化测试与标准认知成套测验结合神经影像学的独立比较。
Independent comparison of CogState computerized testing and a standard cognitive battery with neuroimaging.
作者信息
Mielke Michelle M, Weigand Stephen D, Wiste Heather J, Vemuri Prashanthi, Machulda Mary M, Knopman Davis S, Lowe Val, Roberts Rosebud O, Kantarci Kejal, Rocca Walter A, Jack Clifford R, Petersen Ronald C
机构信息
Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
出版信息
Alzheimers Dement. 2014 Nov;10(6):779-89. doi: 10.1016/j.jalz.2014.09.001. Epub 2014 Nov 15.
BACKGROUND
Inexpensive, non-invasive tools for assessing Alzheimer-type pathophysiologies are needed. Computerized cognitive assessments are prime candidates.
METHODS
Cognitively normal participants, aged 51-71, with magnetic resonance imaging, fluorodeoxyglucose-positron emission tomography (FDG-PET), amyloid PET, CogState computerized cognitive assessment, and standard neuropsychological tests were included. We first examined the association between the CogState battery and neuroimaging measures. We then compared that association to the one between standard neuropsychological z-scores and neuroimaging.
RESULTS
Slower reaction times for CogState Identification and One Back, and lower memory and attention z-scores, were associated (P < .05) with FDG-PET hypometabolism. Slower time on the Groton Maze Learning Task and worse One Card Learning accuracy were associated (P < .05) with smaller hippocampal volumes. There were no associations with amyloid PET. Associations of CogState and neuropsychological Z-scores with neuroimaging were small and of a similar magnitude.
CONCLUSIONS
CogState subtests were cross-sectionally comparable to standard neuropsychological tests in their relatively weak associations with neurodegeneration imaging markers.
背景
需要用于评估阿尔茨海默病类型病理生理学的廉价、非侵入性工具。计算机化认知评估是主要候选方法。
方法
纳入年龄在51 - 71岁、认知正常且进行了磁共振成像、氟脱氧葡萄糖正电子发射断层扫描（FDG - PET）、淀粉样蛋白PET、CogState计算机化认知评估以及标准神经心理学测试的参与者。我们首先检查了CogState成套测试与神经影像学测量之间的关联。然后我们将该关联与标准神经心理学z分数和神经影像学之间的关联进行了比较。
结果
CogState识别和“1 - 回溯”任务中较慢的反应时间，以及较低的记忆和注意力z分数，与FDG - PET代谢减低相关（P < 0.05）。格罗顿迷宫学习任务中较慢的完成时间和单卡片学习较差的准确性与较小的海马体积相关（P < 0.05）。与淀粉样蛋白PET无关联。CogState和神经心理学z分数与神经影像学的关联较小且程度相似。
结论
在与神经退行性变成像标志物的相对较弱关联方面，CogState子测试与标准神经心理学测试在横断面研究中具有可比性。
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