粘质沙雷氏菌临床分离株中的喹诺酮耐药性。
Quinolone resistance in clinical isolates of Serratia marcescens.
作者信息
Fujimaki K, Fujii T, Aoyama H, Sato K, Inoue Y, Inoue M, Mitsuhashi S
机构信息
Episome Institute, Fujimi-mura, Seta-gun, Japan.
出版信息
Antimicrob Agents Chemother. 1989 May;33(5):785-7. doi: 10.1128/AAC.33.5.785.
Abstract
The uptakes of norfloxacin by quinolone-resistant and -susceptible strains of Serratia marcescens were almost the same and 50% inhibitory concentrations for DNA gyrase and the MICs of quinolones were correlated, suggesting that DNA gyrase alterations are the basis of quinolone resistance.
摘要
喹诺酮耐药和敏感的粘质沙雷氏菌菌株对诺氟沙星的摄取几乎相同，并且喹诺酮对DNA回旋酶的50%抑制浓度与最低抑菌浓度相关，这表明DNA回旋酶改变是喹诺酮耐药的基础。
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