Cuomo Francesca, Lopez Francesco, Piludu Marco, Miguel Maria G, Lindman Bjorn, Ceglie Andrea
Dipartimento di Agricoltura, Ambiente Alimenti (DIAAA) and CSGI, Università degli Studi del Molise, Via De Sanctis, I-86100 Campobasso, Italy.
Dipartimento di Agricoltura, Ambiente Alimenti (DIAAA) and CSGI, Università degli Studi del Molise, Via De Sanctis, I-86100 Campobasso, Italy.
J Colloid Interface Sci. 2015 Jun 1;447:211-6. doi: 10.1016/j.jcis.2014.10.060. Epub 2014 Nov 4.
Polymer nanocapsules assembled on cationic liposomes have been built through the layer-by-layer (LbL) technique. Chitosan and alginate, two biocompatible polyelectrolytes, were used to cover the template, where the Rhodamine B was previously loaded. The multishell formed with the alternate deposition of the polyelectrolytes, according to the principles of the LbL assembly, was supposed to change the permeability of the capsule wall. The thickness of the multishell was seen increasing with the number of layers deposited through the observations with the Transmission Electron Microscope. The permeability of the capsules was studied through Rhodamine B release assays. Nanocapsules with seven layers of polyelectrolytes released the dye slowly compared to the capsules with three or five layers. The Ritger-Peppas model was applied to investigate the release mechanisms and a non-Fickian transport behavior was detected regardless of the number of layers. Values of diffusion coefficients of Rhodamine B through the capsule wall were also calculated.
通过层层（LbL）技术构建了组装在阳离子脂质体上的聚合物纳米胶囊。壳聚糖和海藻酸盐这两种生物相容性聚电解质被用于覆盖预先负载了罗丹明B的模板。根据LbL组装原理，通过聚电解质的交替沉积形成的多壳层被认为会改变胶囊壁的渗透性。通过透射电子显微镜观察发现，多壳层的厚度随着沉积层数的增加而增加。通过罗丹明B释放试验研究了胶囊的渗透性。与具有三层或五层的胶囊相比，具有七层聚电解质的纳米胶囊释放染料的速度较慢。应用Ritger-Peppas模型研究释放机制，并且检测到无论层数多少均存在非菲克传输行为。还计算了罗丹明B通过胶囊壁的扩散系数值。
