酿酒酵母中Ty元件及其他插入序列的有丝分裂和减数分裂基因转换
Mitotic and meiotic gene conversion of Ty elements and other insertions in Saccharomyces cerevisiae.
作者信息
Vincent A, Petes T D
机构信息
Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637.
出版信息
Genetics. 1989 Aug;122(4):759-72. doi: 10.1093/genetics/122.4.759.
Abstract
We examined meiotic and mitotic gene conversion events involved in deletion of Ty elements and other insertions from the genome of the yeast Saccharomyces cerevisiae. We found that Ty elements and one other insertion were deleted by mitotic gene conversion less frequently than point mutations at the same loci. One non-Ty insertion similar in size to Ty, however, did not show this bias. Mitotic conversion events deleting insertions were more frequently associated with crossing over than those deleting point mutations. In meiosis, conversion events duplicating the element were more common than those that deleted the element for one of the loci (HIS4) examined.
摘要
我们研究了酿酒酵母基因组中涉及Ty元件缺失及其他插入序列缺失的减数分裂和有丝分裂基因转换事件。我们发现，Ty元件和另一个插入序列通过有丝分裂基因转换而缺失的频率低于同一基因座处的点突变。然而，一个大小与Ty相似的非Ty插入序列并未表现出这种偏向性。与缺失点突变的有丝分裂转换事件相比，删除插入序列的有丝分裂转换事件与交叉的关联更为频繁。在减数分裂中，对于所检测的一个基因座（HIS4）而言，使元件重复的转换事件比删除元件的转换事件更为常见。
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