Bakry Ola Ahmed, El Shazly Rania Mohamed Azmy, El Farargy Shawky Mahmoud, Kotb Dalia
Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufiya University, Menoufiya, Egypt.
Department of Medical Biochemistry, Faculty of Medicine, Menoufiya University, Menoufiya, Egypt.
Indian Dermatol Online J. 2014 Nov;5(Suppl 1):S9-S16. doi: 10.4103/2229-5178.144506.
Acne vulgaris (AV) is a common disease affecting all ages and ethnic groups. Androgens, skin and serum lipids, inflammatory signaling and regulatory neuropeptides seem to be involved in this multi-factorial process.
The aim of this work was to determine hormonal levels and lipid profile in non-obese, non-hirsute females with AV.
A total of 60 non-obese, non-hirsute female cases with different grades of AV and 60 age- and gender-matched healthy volunteers were included. Measurement of serum total and free testosterone, sex hormone binding globulin (SHBG), estradiol and progesterone and blood lipids was done during the luteal phase of the menstrual cycle.
Total testosterone, free testosterone (FT) and progesterone levels were significantly higher (P < 0.001 for all) while estradiol levels (P < 0.001) and SHBG (P < 0.01) were significantly lower in cases than controls. Total cholesterol and low density lipoprotein cholesterol (LDL-C) levels were significantly higher (P < 0.001 for both) while high density lipoprotein cholesterol (HDL-C) and apolipoprotein A-1 (ApoA-1) levels were significantly lower (P < 0.001 for both) in cases than controls. Higher values of FT (P = 0.03) and SHBG (P = 0.02) and lower values of estradiol (P = 0.04) levels were significantly in favor of severe acne. Higher values of cholesterol (P < 0.001) and LDL-C (P = 0.03) and lower values of HDL-C (P = 0.01) and ApoA-1 (P = 0.02) levels were significantly associated with severe acne.
Changes in hormone levels and lipid profile in non-obese and non-hirsute females with AV should be considered in disease pathogenesis and in treatment prescription of these patients.
寻常痤疮（AV）是一种影响所有年龄和种族群体的常见疾病。雄激素、皮肤和血清脂质、炎症信号传导和调节性神经肽似乎都参与了这个多因素过程。
本研究的目的是确定非肥胖、非多毛的寻常痤疮女性患者的激素水平和血脂谱。
共纳入60例不同严重程度的非肥胖、非多毛寻常痤疮女性患者及60例年龄和性别匹配的健康志愿者。在月经周期的黄体期测定血清总睾酮、游离睾酮、性激素结合球蛋白（SHBG）、雌二醇、孕酮和血脂。
与对照组相比，患者组的总睾酮、游离睾酮（FT）和孕酮水平显著升高（均P<0.001），而雌二醇水平（P<0.001）和SHBG（P<0.01）显著降低。患者组的总胆固醇和低密度脂蛋白胆固醇（LDL-C）水平显著升高（均P<0.001），而高密度脂蛋白胆固醇（HDL-C）和载脂蛋白A-1（ApoA-1）水平显著降低（均P<0.001）。FT（P=0.03）和SHBG（P=0.02）值较高以及雌二醇水平（P=0.04）较低显著提示重度痤疮。胆固醇（P<0.001）和LDL-C（P=0.03）值较高以及HDL-C（P=0.01）和ApoA-1（P=0.02）值较低与重度痤疮显著相关。
在这些患者的疾病发病机制和治疗处方中，应考虑非肥胖、非多毛寻常痤疮女性患者激素水平和血脂谱的变化。
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