Desel H
Giftinformationszentrum-Nord der Länder Bremen, Hamburg, Niedersachsen und Schleswig-Holstein (GIZ-Nord) und Rechtsmedizinisches Labor für forensisch-toxikologische Analytik und klinisch-toxikologisches Labor, Universitätsmedizin Göttingen - Georg-August-Universität, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland,
Med Klin Intensivmed Notfmed. 2015 Feb;110(1):15-20. doi: 10.1007/s00063-014-0411-y. Epub 2014 Dec 18.
Mass poisoning events are rare and different in some respects from other mass casualties, especially with regard to diagnosis and triage.
Based on the description of important historical events and experiences of poison control centers, an overview is provided for different types of mass poisoning events as well as guidelines for specific medical management.
The review is based on a literature search and case reports notified to the Giftinformationszentrum-Nord Poisons Center.
Toxicological risk assessment is based on identification of all relevant agents, evaluation of their toxic hazards (toxicity), and evaluation of the exposure (dose and pathway) for all persons exposed. This risk assessment constitutes the basis of medical diagnosis and management. In cases of suspicion of poisoning or poisonings caused by illegal drugs, risk assessment may be difficult due to the lack of important data needed for risk assessment. Mass poisonings caused by ethanol or contaminated food are well understood, with therapy being mainly symptomatic. However, in rare poisonings by other agents, a specific antidote treatment may be important. Thus, adequate antidote supplies must be available for these events.
As hardly any medical professional has personal practical knowledge of mass poisoning casualties, such events are unique experiences. Thorough preparation and intensive cooperation with poison control centers and-if applicable-public health authorities may be important for best practice event management.
群体中毒事件较为罕见,在某些方面与其他群体伤亡事件有所不同,尤其是在诊断和分诊方面。
基于对重要历史事件和中毒控制中心经验的描述,对不同类型的群体中毒事件进行概述,并提供具体医疗管理指南。
本综述基于文献检索以及向北方毒物信息中心报告的病例报告。
毒理学风险评估基于识别所有相关毒物、评估其毒性危害(毒性)以及评估所有暴露人员的暴露情况(剂量和途径)。这种风险评估构成了医学诊断和管理的基础。在怀疑中毒或由非法药物引起的中毒事件中,由于缺乏风险评估所需的重要数据,风险评估可能会很困难。由乙醇或受污染食物引起的群体中毒已为人熟知,治疗主要是对症治疗。然而,在其他毒物引起的罕见中毒事件中,特定的解毒剂治疗可能很重要。因此,必须为这些事件准备充足的解毒剂。
由于几乎没有医疗专业人员对群体中毒伤亡事件有个人实践经验,此类事件是独特的经历。充分准备并与中毒控制中心以及(如适用)公共卫生当局密切合作,对于最佳实践的事件管理可能很重要。