Haglund C, Roberts P J, Nordling S
Fourth Department of Surgery, Helsinki University Central Hospital, Finland.
J Clin Pathol. 1989 Sep;42(9):927-30. doi: 10.1136/jcp.42.9.927.
The distribution of laminin, a basement membrane glycoprotein, was studied by an immunohistochemical technique in six samples of benign sclerosing lesions of extrahepatic bile ducts and in 11 sclerosing cholangiocarcinomas. The expression of laminin showed that benign glandular structures were surrounded by a mainly intact basement membrane. In sclerosing cholangiocarcinomas laminin was irregularly distributed, and in large areas totally absent. The findings suggest that deposition of basement membrane material is defective. Sclerosing cholangitis may be extremely difficult to distinguish from well differentiated sclerosing cholangiocarcinoma. This sample was small, but the diseases studied were relatively rare. Staining for laminin might be of additional use to surgical pathologists in the differential diagnosis of benign sclerosing lesions and sclerosing cholangiocarcinomas.
采用免疫组织化学技术，对6例肝外胆管良性硬化性病变样本和11例硬化性胆管癌样本中基底膜糖蛋白层粘连蛋白的分布进行了研究。层粘连蛋白的表达显示，良性腺结构被基本完整的基底膜所包围。在硬化性胆管癌中，层粘连蛋白分布不规则，且大片区域完全缺失。这些发现提示基底膜物质的沉积存在缺陷。硬化性胆管炎可能极难与高分化硬化性胆管癌相鉴别。本样本量较小，但所研究的疾病相对罕见。层粘连蛋白染色可能有助于外科病理学家对良性硬化性病变和硬化性胆管癌进行鉴别诊断。
