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加速实现消除结核病的进展:联合治疗与预防的必要性。

Accelerating progress towards tuberculosis elimination: the need for combination treatment and prevention.

作者信息

Reid A, Grant A D, White R G, Dye C, Vynnycky E, Fielding K, Churchyard G, Pillay Y

机构信息

Joint United Nations Programme on HIV/AIDS Country Office, Pretoria, South Africa.

London School of Hygiene & Tropical Medicine, London, UK.

出版信息

Int J Tuberc Lung Dis. 2015 Jan;19(1):5-9. doi: 10.5588/ijtld.14.0078.

DOI:10.5588/ijtld.14.0078
PMID:25519784
Abstract

Although estimated tuberculosis (TB) incidence is now falling globally, we are unlikely to achieve the Millennium Development Goal (MDG) TB targets without changing the emphasis of the global TB response in high human immunodeficiency virus prevalence settings. Two independent modelling exercises using South African data with different structures and assumptions conclude that, until new drugs, diagnostics and vaccines are available, a fully funded and accessible combination approach to anti-tuberculosis treatment and prevention, based on knowledge of local TB epidemiology and evidence-informed policy, is essential to accelerate progress towards zero new tuberculous infections, zero TB deaths and zero suffering from TB.

摘要

尽管目前全球估计的结核病发病率正在下降,但如果不改变全球结核病应对措施在人类免疫缺陷病毒高流行地区的重点,我们不太可能实现千年发展目标中的结核病目标。两项使用不同结构和假设的南非数据进行的独立建模得出结论,在有新药、诊断方法和疫苗可用之前,基于当地结核病流行病学知识和循证政策,采用资金充足且可及的抗结核治疗与预防相结合的方法,对于加快实现零新增结核感染、零结核病死亡和零结核病痛苦的目标至关重要。

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