Chao Pei-Chun, Hsu Cheng-Chin, Liu Wen-Hu
School of Nutrition, Chung Shan Medical University, Taichung, Taiwan ; Department of Nutrition, Chung Shan Medical University Hospital, Taichung, Taiwan.
Biomedicine (Taipei). 2014;4(3):18. doi: 10.7603/s40681-014-0018-x. Epub 2014 Aug 13.
Background: Purple laver (() is a popular edible seaweed in Asia. This study examined protective effects of extract from purple laver extract (PLE) in diabetic mice. Methods: Content of carotenoids and anthocyanins in PLE was analyzed. PLE at 0.5 and 1% was supplied for 7 weeks. Results: PLE was rich in anthocyanins. PLE intake at 0.5 and 1% lowered plasma glucose level (P<0.05); only at 1% raised plasma insulin level, and decreased plasma triglyceride and total cholesterol levels (P<0.05). PLE treatments at 1% lowered hepatic triglyceride and total cholesterol (P<0.05); it reduced renal reactive oxygen species level (P<0.05); retained renal glutathione level, maintaining renal glutathione peroxidase and catalase activities (P<0.05). Conclusion: aqueous extract could attenuate diabetic progression via anti-oxidative and lipid lowering effects. This seaweed could be considered as potent healthy food, and used for personalized medicine.
紫菜是亚洲一种受欢迎的可食用海藻。本研究检测了紫菜提取物（PLE）对糖尿病小鼠的保护作用。方法：分析了PLE中类胡萝卜素和花青素的含量。以0.5%和1%的剂量供应PLE，持续7周。结果：PLE富含花青素。摄入0.5%和1%的PLE可降低血糖水平（P<0.05）；仅1%的剂量可提高血浆胰岛素水平，并降低血浆甘油三酯和总胆固醇水平（P<0.05）。1%的PLE处理可降低肝脏甘油三酯和总胆固醇水平（P<0.05）；降低肾脏活性氧水平（P<0.05）；维持肾脏谷胱甘肽水平，保持肾脏谷胱甘肽过氧化物酶和过氧化氢酶活性（P<0.05）。结论：紫菜水提取物可通过抗氧化和降血脂作用减轻糖尿病进展。这种海藻可被视为一种有效的健康食品，并用于个性化医疗。
