假说：褪黑素受体在白癜风中的可能作用：讨论文件
Hypothesis: possible role for the melatonin receptor in vitiligo: discussion paper.
作者信息
Slominski A, Paus R, Bomirski A
机构信息
Department of Dermatology, Yale University, School of Medicine, New Haven, CT 06510.
出版信息
J R Soc Med. 1989 Sep;82(9):539-41. doi: 10.1177/014107688908200911.
Abstract
A new unifying hypothesis for the aetiology of vitiligo is proposed, in which we postulate that the final destruction of melanocytes in vitiligo results from a cascade of reactions initiated by a disregulation of melanogenesis, caused by activation of the melatonin receptor. These events result in the high and uncontrolled production of free radicals and toxic products of melanogenesis which sequentially damage or destroy melanocytes and keratinocytes, provoke an autoimmune response against exposed intracellular or altered cell surface antigens, and increase the propensity of melanocytes to undergo malignant transformation.
摘要
我们提出了一种关于白癜风病因的新统一假说，其中我们假定，白癜风中黑素细胞的最终破坏是由褪黑素受体激活导致黑素生成失调引发的一系列反应所致。这些事件导致自由基和黑素生成有毒产物的大量且不受控制的产生，进而依次损害或破坏黑素细胞和角质形成细胞，引发针对暴露的细胞内或改变的细胞表面抗原的自身免疫反应，并增加黑素细胞发生恶性转化的倾向。
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