Università di Padova, Dipartimento di Scienze Chimiche , via Marzolo 1, Padova, Italy.
J Am Chem Soc. 2015 Jan 21;137(2):886-92. doi: 10.1021/ja511205e. Epub 2015 Jan 12.
Monolayer-protected nanoparticles provide a straightforward access to self-organized receptors that selectively bind different substrates in water. Molecules featuring different kinds of noncovalent interactions (namely, hydrophobic, ion pairing, and metal-ligand coordination) can be grafted on the nanoparticle surface to provide tailored binding sites for virtually any class of substrate. Not only the selectivity but also the strength of these interactions can be modulated. Such recognition ability can be exploited with new sensing protocols, based on NMR magnetization transfer and diffusion-ordered spectroscopy (DOSY), to detect and identify organic molecules in complex mixtures.
单层保护纳米粒子为自组装受体提供了一种直接的途径，这些受体可以在水中选择性地结合不同的底物。具有不同非共价相互作用（即疏水作用、离子配对和金属-配体配位）的分子可以接枝到纳米粒子表面，为几乎任何一类底物提供定制的结合位点。不仅可以调节这些相互作用的选择性，还可以调节其强度。这种识别能力可以通过新的基于 NMR 磁化转移和扩散有序光谱（DOSY）的传感方案来利用，以检测和识别复杂混合物中的有机分子。
