Low Gavin, Owen Nicola E, Joubert Ilse, Patterson Andrew J, Graves Martin J, Glaser Kevin J, Alexander Graeme J M, Lomas David J
Department of Radiology, Addenbrooke's Hospital, University of Cambridge, England, United Kingdom.
University of Alberta, Edmonton, Alberta, Canada.
J Magn Reson Imaging. 2015 Sep;42(3):844-50. doi: 10.1002/jmri.24826. Epub 2014 Dec 24.
To evaluate the reliability of MRE using a spin-echo echo-planar imaging (SE-EPI) renal MRE technique in healthy volunteers.
Institutional review board approved prospective study in which all participants provided written informed consent. Sixteen healthy volunteers comprising seven males and nine females with a median age of 35 years (age range: 23 to 59 years) were included. Coronal 90 Hz and 60 Hz MRE acquisitions were performed twice within a 30-min interval between examinations. Renal MRE reliability was assessed by (i) test-retest repeatability, and (ii) inter-rater agreement between two independent readers. The MRE-measured averaged renal stiffness values were evaluated using: intraclass correlation coefficient (ICC), Bland-Altman and the within-subject coefficient of variation (COV).
For test-retest repeatability, Bland-Altman showed a mean stiffness difference between examinations of 0.07 kPa (95% limits of agreement: -1.41, 1.54) at 90 Hz and 0.01 kPa (95% limits of agreement: -0.51, 0.53) at 60 Hz. Coefficient of repeatability was 1.47 kPa and 0.52 kPa at 90 Hz and 60 Hz, respectively. The within-subject COV was 13.6% and 7.7% at 90 Hz and 60 Hz, respectively. ICC values were 0.922 and 0.907 for test-retest repeatability and 0.998 and 0.989 for inter-rater agreement, respectively (P < 0.001).
SE-EPI renal MRE is a reliable technique.
使用自旋回波平面成像（SE-EPI）肾脏磁共振弹性成像（MRE）技术评估健康志愿者中MRE的可靠性。
经机构审查委员会批准的前瞻性研究，所有参与者均提供书面知情同意书。纳入16名健康志愿者，其中7名男性和9名女性，中位年龄35岁（年龄范围：23至59岁）。在两次检查之间的30分钟间隔内，对冠状面90 Hz和60 Hz的MRE进行两次采集。通过（i）重测重复性和（ii）两名独立阅片者之间的阅片者间一致性评估肾脏MRE的可靠性。使用组内相关系数（ICC）、Bland-Altman法和受试者内变异系数（COV）评估MRE测量的平均肾脏硬度值。
对于重测重复性，Bland-Altman法显示，90 Hz时两次检查之间的平均硬度差异为0.07 kPa（95%一致性界限：-1.41，1.54），60 Hz时为0.01 kPa（95%一致性界限：-0.51，0.53）。90 Hz和60 Hz时的重复性系数分别为1.47 kPa和0.52 kPa。90 Hz和60 Hz时受试者内COV分别为13.6%和7.7%。重测重复性的ICC值分别为0.922和0.907，阅片者间一致性的ICC值分别为0.998和0.989（P < 0.001）。
SE-EPI肾脏MRE是一种可靠的技术。
