Hur Sun, Han Gun-Soo, Cho Byung-Jun
Division of Sport Science, Kangwon National University, Republic of Korea.
Department of Sports and Leisure Studies, College of Humanity, Daegu University, Republic of Korea.
J Phys Ther Sci. 2014 Dec;26(12):1933-6. doi: 10.1589/jpts.26.1933. Epub 2014 Dec 25.
[Purpose] The purpose of this study was to investigate the effects of exercise therapy on glucose, TNF-α and IL-6 blood levels in middle-aged women. [Subjects] A total of 46 participants were assigned to four groups: Type D personality+Exercise (n=12), Type D+no-Exercise (n=12), not-Type D+Exercise (n=12), and not-Type D+no-Exercise (n=10). [Methods] Blood glucose was measured by the hexokinase method. An enzyme-linked immunosorbent assay (ELISA) was used to measure the circulating plasma levels of TNF-α and IL-6 (Quantikine HS, R&D Systems, Minneapolis, USA). An aerobic exercise program and meditation were conducted in parallel by the Exercise groups for 10 months. Stretching was performed for 10 min as a warm-up, and then walking and running on a treadmill at 60 to 70% of HRmax were performed for 40 min three times a week. Blood samples were processed according to standard laboratory procedures. [Results] Fasting glucose showed a significant interaction effect among groups, group×time, and post-test. TNF-α showed a significant difference among groups, and was lower in the not-Type D personality+Exercise group than in the other three groups. IL-6 showed a significant difference among the groups. [Conclusion] In conclusion, personality may affect the established effect of exercise on cytokine activity. Type D personality was independently associated with significant immune activation, and increase in TNF-α activity was observed among Type D participants.
[目的] 本研究旨在探讨运动疗法对中年女性血糖、肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）血液水平的影响。[对象] 共有46名参与者被分为四组：D型人格+运动组（n = 12）、D型人格+不运动组（n = 12）、非D型人格+运动组（n = 12）和非D型人格+不运动组（n = 10）。[方法] 采用己糖激酶法测量血糖。使用酶联免疫吸附测定法（ELISA）测量循环血浆中TNF-α和IL-6的水平（Quantikine HS，美国明尼阿波利斯市R&D Systems公司）。运动组同时进行了为期10个月的有氧运动计划和冥想。先进行10分钟的伸展运动作为热身，然后每周三次在跑步机上以心率储备（HRmax）的60%至70%进行40分钟的步行和跑步。血样按照标准实验室程序进行处理。[结果] 空腹血糖在组间、组×时间和测试后显示出显著的交互作用。TNF-α在组间存在显著差异，非D型人格+运动组的TNF-α水平低于其他三组。IL-6在组间也存在显著差异。[结论] 总之，人格可能会影响运动对细胞因子活性的既定效果。D型人格与显著的免疫激活独立相关，且在D型参与者中观察到TNF-α活性增加。
