银纳米颗粒：合成、性质及治疗应用。
Silver nanoparticles: synthesis, properties, and therapeutic applications.
作者信息
Wei Liuya, Lu Jingran, Xu Huizhong, Patel Atish, Chen Zhe-Sheng, Chen Guofang
机构信息
School of Pharmacy, Weifang Medical University, Weifang 261053, People's Republic of China; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John's University, Queens, NY 11439, USA.
Department of Chemistry, St John's College of Liberal Arts and Science, St John's University, Queens, NY 11439, USA.
出版信息
Drug Discov Today. 2015 May;20(5):595-601. doi: 10.1016/j.drudis.2014.11.014. Epub 2014 Dec 24.
Abstract
Silver nanoparticles (AgNPs) have been widely used in biomedical fields because of their intrinsic therapeutic properties. Here, we introduce methods of synthesizing AgNPs and discuss their physicochemical, localized surface plasmon resonance (LSPR) and toxicity properties. We also review the impact of AgNPs on human health and the environment along with the underlying mechanisms. More importantly, we highlight the newly emerging applications of AgNPs as antiviral agents, photosensitizers and/or radiosensitizers, and anticancer therapeutic agents in the treatment of leukemia, breast cancer, hepatocellular carcinoma, lung cancer, and skin and/or oral carcinoma.
摘要
银纳米颗粒（AgNPs）因其固有的治疗特性而在生物医学领域得到广泛应用。在此，我们介绍了合成AgNPs的方法，并讨论了它们的物理化学性质、局域表面等离子体共振（LSPR）和毒性特性。我们还综述了AgNPs对人类健康和环境的影响以及潜在机制。更重要的是，我们重点介绍了AgNPs作为抗病毒剂、光敏剂和/或放射增敏剂以及抗癌治疗剂在治疗白血病、乳腺癌、肝细胞癌、肺癌以及皮肤和/或口腔癌方面的新出现的应用。
相似文献
1
Silver nanoparticles: synthesis, properties, and therapeutic applications.银纳米颗粒：合成、性质及治疗应用。
Drug Discov Today. 2015 May;20(5):595-601. doi: 10.1016/j.drudis.2014.11.014. Epub 2014 Dec 24.
2
Silver Nanoparticles: Synthesis and Application for Nanomedicine.银纳米粒子：用于纳米医学的合成与应用。
Int J Mol Sci. 2019 Feb 17;20(4):865. doi: 10.3390/ijms20040865.
3
Advances in therapeutic applications of silver nanoparticles.银纳米粒子治疗应用的新进展。
Chem Biol Interact. 2023 Sep 1;382:110590. doi: 10.1016/j.cbi.2023.110590. Epub 2023 Jun 1.
4
Silver nanoparticles: a novel radiation sensitizer for glioma?银纳米粒子：胶质瘤的新型辐射增敏剂？
Nanoscale. 2013 Dec 7;5(23):11829-36. doi: 10.1039/c3nr01351k. Epub 2013 Oct 15.
5
Is the autophagy a friend or foe in the silver nanoparticles associated radiotherapy for glioma?自噬在银纳米颗粒联合放射治疗脑胶质瘤中是敌是友？
Biomaterials. 2015 Sep;62:47-57. doi: 10.1016/j.biomaterials.2015.05.033. Epub 2015 May 19.
6
Evaluating cell specific cytotoxicity of differentially charged silver nanoparticles.评价不同荷质比的银纳米粒子的细胞特异性细胞毒性。
Food Chem Toxicol. 2013 Jan;51:1-14. doi: 10.1016/j.fct.2012.08.044. Epub 2012 Aug 30.
7
Biomolecule-assisted synthesis of water-soluble silver nanoparticles and their biomedical applications.生物分子辅助合成水溶性银纳米颗粒及其生物医学应用。
Inorg Chem. 2008 Jul 7;47(13):5882-8. doi: 10.1021/ic8002228. Epub 2008 May 23.
8
Cancer Radiosensitizers.癌症增敏剂。
Trends Pharmacol Sci. 2018 Jan;39(1):24-48. doi: 10.1016/j.tips.2017.11.003. Epub 2017 Dec 7.
9
Controlled-release systems for metal-based nanomedicine: encapsulated/self-assembled nanoparticles of anticancer gold(III)/platinum(II) complexes and antimicrobial silver nanoparticles.基于金属的纳米医学的控释系统：封装/自组装的抗癌金(III)/铂(II)配合物和抗菌银纳米粒子的纳米粒子。
Adv Mater. 2014 Aug 20;26(31):5550-7. doi: 10.1002/adma.201305617. Epub 2014 Mar 24.
10
Gold Nanoparticles: Recent Advances in the Biomedical Applications.金纳米颗粒：生物医学应用的最新进展
Cell Biochem Biophys. 2015 Jul;72(3):771-5. doi: 10.1007/s12013-015-0529-4.
引用本文的文献
1
Plasmon-Enhanced Fluorescence Determination of Tamsulosin Using Silver Nanoparticles: A Green Analytical Strategy.基于银纳米颗粒的血浆增强荧光法测定坦索罗辛：一种绿色分析策略。
J Fluoresc. 2025 Sep 17. doi: 10.1007/s10895-025-04545-y.
2
Green Synthesis of Silver Nanoparticles and Polymeric Nanofiber Composites: Fabrications, Mechanisms, and Applications.银纳米颗粒与聚合物纳米纤维复合材料的绿色合成：制备、机理及应用
Polymers (Basel). 2025 Aug 28;17(17):2327. doi: 10.3390/polym17172327.
3
Biogenic Synthesis of Silver Nanoparticles and Their Diverse Biomedical Applications.银纳米颗粒的生物合成及其多样的生物医学应用。
Molecules. 2025 Jul 24;30(15):3104. doi: 10.3390/molecules30153104.
4
Leaf flower: green-synthesized silver nanoparticles from leaf extract reveal superior antimicrobial and cytotoxic efficacy.叶花：从叶提取物中绿色合成的银纳米颗粒具有卓越的抗菌和细胞毒性功效。
RSC Adv. 2025 Jul 8;15(29):23654-23669. doi: 10.1039/d5ra02434j. eCollection 2025 Jul 4.
5
Nanomedicine Approaches for Autophagy Modulation in Cancer Therapy.癌症治疗中自噬调节的纳米医学方法
Small Sci. 2025 Apr 11;5(6):2400607. doi: 10.1002/smsc.202400607. eCollection 2025 Jun.
6
Sustainable production and antibacterial efficacy of silver nanoparticles on cellulose nanofibers from mushroom waste.银纳米颗粒对蘑菇废料纤维素纳米纤维的可持续生产及抗菌功效
RSC Adv. 2025 Jun 11;15(25):19726-19740. doi: 10.1039/d5ra02087e. eCollection 2025 Jun 10.
7
Biosynthesis of silver nanoparticles from plant extracts: a comprehensive review focused on anticancer therapy.植物提取物合成银纳米颗粒：聚焦抗癌治疗的综合综述
Front Pharmacol. 2025 May 14;16:1600347. doi: 10.3389/fphar.2025.1600347. eCollection 2025.
8
The role of silver nanoparticles in yellow lupine (Lupinus luteus L.) defense response to Fusarium oxysporum f.sp. lupini.银纳米颗粒在黄羽扇豆（Lupinus luteus L.）对尖孢镰刀菌 lupini 专化型防御反应中的作用。
Sci Rep. 2025 May 8;15(1):16136. doi: 10.1038/s41598-025-00464-x.
9
Formulation and clinical translation of inhalable nanomedicines for the treatment and prevention of pulmonary infectious diseases.用于治疗和预防肺部感染性疾病的可吸入纳米药物的制剂与临床转化
Drug Deliv Transl Res. 2025 Apr 29. doi: 10.1007/s13346-025-01861-5.
10
Bacterial responses to stem extract and green-synthesized Ag-TiO and Ag-SeO core/shell nanocomposites: unveiling antimicrobial and antioxidant properties.细菌对茎提取物以及绿色合成的Ag-TiO和Ag-SeO核壳纳米复合材料的反应：揭示抗菌和抗氧化特性。
RSC Adv. 2025 Apr 24;15(17):13152-13171. doi: 10.1039/d5ra00936g. eCollection 2025 Apr 22.
本文引用的文献
1
Different Plasmon Sensing Behavior of Silver and Gold Nanorods.银和金纳米棒的不同表面等离子体传感行为。
J Phys Chem Lett. 2013 May 2;4(9):1541-5. doi: 10.1021/jz4005015. Epub 2013 Apr 22.
2
A novel green synthesis approach for polymer nanocomposites decorated with silver nanoparticles and their antibacterial activity.一种用于制备负载银纳米颗粒的聚合物纳米复合材料的新型绿色合成方法及其抗菌活性。
Analyst. 2014 Nov 21;139(22):5793-9. doi: 10.1039/c4an01301h.
3
Etchable plasmonic nanoparticle probes to image and quantify cellular internalization.可刻蚀等离子体纳米颗粒探针用于成像和量化细胞内化。
Nat Mater. 2014 Sep;13(9):904-11. doi: 10.1038/nmat3982. Epub 2014 Jun 8.
4
The optical, photothermal, and facile surface chemical properties of gold and silver nanoparticles in biodiagnostics, therapy, and drug delivery.金和银纳米颗粒在生物诊断、治疗及药物递送方面的光学、光热和易调控的表面化学性质。
Arch Toxicol. 2014 Jul;88(7):1391-417. doi: 10.1007/s00204-014-1245-3. Epub 2014 Jun 4.
5
Nanosilver particles in medical applications: synthesis, performance, and toxicity.医学应用中的纳米银颗粒：合成、性能及毒性
Int J Nanomedicine. 2014 May 16;9:2399-407. doi: 10.2147/IJN.S55015. eCollection 2014.
6
Silver nanoparticles: therapeutical uses, toxicity, and safety issues.银纳米颗粒：治疗用途、毒性及安全性问题。
J Pharm Sci. 2014 Jul;103(7):1931-1944. doi: 10.1002/jps.24001. Epub 2014 May 13.
7
A tumor-targeting near-infrared laser-triggered drug delivery system based on GO@Ag nanoparticles for chemo-photothermal therapy and X-ray imaging.基于 GO@Ag 纳米粒子的肿瘤靶向近红外激光触发药物传递系统用于化学-光热治疗和 X 射线成像。
Biomaterials. 2014 Jul;35(22):5847-61. doi: 10.1016/j.biomaterials.2014.03.042. Epub 2014 Apr 17.
8
The cellular uptake and cytotoxic effect of silver nanoparticles on chronic myeloid leukemia cells.银纳米粒子对慢性髓系白血病细胞的细胞摄取和细胞毒性作用。
J Biomed Nanotechnol. 2014 Apr;10(4):669-78. doi: 10.1166/jbn.2014.1625.
9
Toxicity Effect of Silver Nanoparticles on Mice Liver Primary Cell Culture and HepG2 Cell Line.银纳米颗粒对小鼠肝脏原代细胞培养物和HepG2细胞系的毒性作用
Iran J Pharm Res. 2014 Winter;13(1):235-42.
10
The surprising in vivo instability of near-IR-absorbing hollow Au-Ag nanoshells.近红外吸收中空金-银纳米壳在体内出人意料的不稳定性。
ACS Nano. 2014 Apr 22;8(4):3222-31. doi: 10.1021/nn405663h. Epub 2014 Feb 25.
Zotero 插件