非人灵长类动物模型对人类疫苗研发的贡献。
The contribution of non-human primate models to the development of human vaccines.
作者信息
Rivera-Hernandez Tania, Carnathan Diane G, Moyle Peter M, Toth Istvan, West Nicholas P, Young Paul R, Silvestri Guido, Walker Mark J
机构信息
School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD, 4072, Australia.
Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA.
出版信息
Discov Med. 2014 Dec;18(101):313-22.
Abstract
The non-human primates (NHPs) model in biomedical research has contributed to the study of human infectious, autoimmune, oncogenic, and neurological diseases. This review focuses on the importance of NHP models in vaccine development for tuberculosis, pertussis, Dengue, group A streptococcus (Streptococcus pyogenes) infection, HIV infection, and certain diseases in the elderly (influenza, for example). From understanding disease pathogenesis and mechanisms of protection, to assessing vaccine safety and efficacy, we discuss selected cases where the importance of the use of NHP models is highlighted.
摘要
非人类灵长类动物（NHPs）模型在生物医学研究中对人类感染性疾病、自身免疫性疾病、肿瘤性疾病和神经疾病的研究发挥了作用。本综述重点关注非人类灵长类动物模型在结核病、百日咳、登革热、A组链球菌（化脓性链球菌）感染、HIV感染以及某些老年疾病（例如流感）疫苗研发中的重要性。从理解疾病发病机制和保护机制，到评估疫苗安全性和有效性，我们讨论了一些突出使用非人类灵长类动物模型重要性的特定案例。
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