干细胞与子宫内膜异位症：新知识可能催生新疗法。
Stem cell and endometriosis: new knowledge may be producing novel therapies.
作者信息
Yang Jing, Huang Fengying
机构信息
Department of Obstetrics and Gynecology, The Second Xiangya Hospital, Central South University Changsha 410011, Hunan, China.
出版信息
Int J Clin Exp Med. 2014 Nov 15;7(11):3853-8. eCollection 2014.
The human endometrium is a dynamic tissue, which undergoes cycles of growth and regression with each menstrual cycle. Adult progenitor stem cells are likely responsible for this remarkable regenerative capacity; these same progenitor stem cells may also have an enhanced capacity to generate endometriosis if shed in a retrograde fashion. The progenitor stem cells reside in the uterus, and, however, may also travel from other tissues such as bone marrow to repopulate the progenitor population. Mesenchymal stem cells are also involved in the pathogenesis of endometriosis and may be the principle source of endometriosis outside of the peritoneal cavity when they differentiate into endometriosis in ectopic locations. The present short review mainly summarizes the latest observations contributing to the current knowledge regarding the presence and the potential contribution of stem cells in the etiology of endometriosis. All these data can have clinical implications and provide a basis for new potential therapeutic applications.
人类子宫内膜是一种动态组织，在每个月经周期都会经历生长和消退的循环。成年祖干细胞可能是这种显著再生能力的原因；如果这些相同的祖干细胞以逆行方式脱落，它们产生子宫内膜异位症的能力可能也会增强。祖干细胞存在于子宫中，然而，它们也可能从骨髓等其他组织迁移过来，以重新填充祖细胞群体。间充质干细胞也参与子宫内膜异位症的发病机制，当它们在异位部位分化为子宫内膜异位症时，可能是腹膜腔外子宫内膜异位症的主要来源。本简短综述主要总结了有助于当前关于干细胞在子宫内膜异位症病因中的存在及其潜在作用的最新观察结果。所有这些数据都可能具有临床意义，并为新的潜在治疗应用提供依据。
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