Fei Xiawei, Shen Yanting, Li Xiaogong, Guo Hongqian
Department of Urology, The Affiliated Nanjing Drum Tower Hospital, Medical School of Nanjing University Nanjing, China.
Research Center of Learning Science, Southeast University Nanjing, China.
Int J Clin Exp Med. 2014 Nov 15;7(11):3881-91. eCollection 2014.
Many studies have focused on the association of tea consumption and the risk and progression of prostate cancer (PCa). However, the evidence is inadequate to draw robust conclusions. To shed light on these inconclusive findings, we conducted a meta-analysis. We searched the database of PubMed and Web of Science for eligible articles. The relevant data were abstracted by two independent reviewers and performed with Stata 11.0. 21 studies were included. The pooled outcomes showed that there was a significant association between tea consumption and PCa risk (OR=0.84, 95% CI (0.71-0.98)); tea consumption could reduce PCa risk in China and India (OR=0.40 and 0.48, 95% CI (0.25-0.66) and (0.24-0.97), respectively); both green and black tea consumption showed no significant effect on PCa risk (OR=0.73 and 0.95, 95% CI (0.52-1.02) and (0.82-1.11), respectively); the highest level tea consumption showed significant protective effect on the low-grade PCa (OR=0.66, 95% CI (0.46-0.93)); no significant effect was found in both localized and advanced PCa in stage subgroup analyses (OR=1.12 and 0.85, 95% CI (0.82-1.54) and (0.62-1.16), respectively). The results show that regardless of tea type, tea consumption might be a potential protective factor for the PCa, especially in China and India. Tea consumption might be the protective factor for low-grade PCa. However, more relevant studies are needed to further explore this association.
许多研究都聚焦于饮茶与前列腺癌（PCa）风险及进展之间的关联。然而，现有证据尚不足以得出确凿结论。为阐明这些尚无定论的研究结果，我们进行了一项荟萃分析。我们在PubMed和Web of Science数据库中搜索符合条件的文章。相关数据由两名独立评审员提取，并使用Stata 11.0进行分析。共纳入21项研究。汇总结果显示，饮茶与PCa风险之间存在显著关联（OR = 0.84，95%可信区间（0.71 - 0.98））；在中国和印度，饮茶可降低PCa风险（OR分别为0.40和0.48，95%可信区间分别为（0.25 - 0.66）和（0.24 - 0.97））；饮用绿茶和红茶对PCa风险均无显著影响（OR分别为0.73和0.95，95%可信区间分别为（0.52 - 1.02）和（0.82 - 1.11））；最高水平的饮茶对低级别PCa有显著保护作用（OR = 0.66，95%可信区间（0.46 - 0.93））；在分期亚组分析中，局部和晚期PCa均未发现显著影响（OR分别为1.12和0.85，95%可信区间分别为（0.82 - 1.54）和（0.62 - 1.16））。结果表明，无论茶的类型如何，饮茶可能是PCa的潜在保护因素，尤其是在中国和印度。饮茶可能是低级别PCa的保护因素。然而，需要更多相关研究来进一步探究这种关联。
